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SH3RF1 encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Additionally we are shipping SH3RF1 Antibodies (42) and SH3RF1 Proteins (4) and many more products for this protein.
the active JNK (show MAPK8 ELISA Kits) signaling complex formed of POSH and the JNK (show MAPK8 ELISA Kits) module is essential for the expression of anterior neural genes and apoptosis in anterior development
These results show that POSH plays a critical role in the progression of epileptic seizures via N-methyl-D-aspartate receptor (show GRIN1 ELISA Kits) trafficking
Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein.
We found a genome-wide significant association for rs2282987 in CDK6 (show CDK6 ELISA Kits) and a consistent association for rs2706748 in SH3RF1 .
The data presented here define POSH and Siah2 (show SIAH2 ELISA Kits) as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy.
POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts
POSH disassociates from the JNK (show MAPK8 ELISA Kits) complex after phosphorylation of MLK3 (show MAP3K11 ELISA Kits) by Akt2 (show AKT2 ELISA Kits), which leads to down-regulation of the JNK (show MAPK8 ELISA Kits) signaling pathway
Results identified ALIX (show PDCD6IP ELISA Kits) as an ubiquitination substrate of POSH and indicate that POSH and ALIX (show PDCD6IP ELISA Kits) cooperate to facilitate efficient virus release.
POSH inhibits ROMK (show KCNJ1 ELISA Kits) channels by enhancing dynamin (show DNM1 ELISA Kits)-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK (show KCNJ1 ELISA Kits) channels.
this study shows that POSH is essential for the integration of cell-type-specific signals that regulate the differentiation, survival, and function of T cells
identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1 (show MAPK8IP1 ELISA Kits)) as a multiprotein scaffold network for TCR-mediated JNK1 (show MAPK8 ELISA Kits) activation in CD8 (show CD8A ELISA Kits)(+) T cells.
a mechanism by which POSH regulates the localization of activated Rac1 and F-actin assembly to control PCDLP formation and subsequent somal translocation of migratory neurons.
An intracellular signaling pathway for process outgrowth inhibition by Nogo66 implicates the POSH complex as a therapeutic target to enhance axon outgrowth and plasticity in the injured central nervous system.
Siah1 (show SIAH1 ELISA Kits) is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK (show MAPK8 ELISA Kits) pathway
POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP (show SMAD4 ELISA Kits) apoptotic complex), that includes all of the known kinase components of the pathway.
Results suggest that the molecular scaffold protein POSH assembles an inhibitory complex that links to the actin-myosin network to regulate neuronal process outgrowth.
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
SH3 multiple domains 2
, SH3 domain containing ring finger 1
, putative E3 ubiquitin-protein ligase SH3RF1
, plenty of SH3s
, SH3 domain-containing RING finger protein 1
, E3 ubiquitin-protein ligase SH3RF1
, SH3 multiple domains protein 2
, plenty of SH3 domains
, ring finger protein 142
, putative scaffolding protein POSH