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anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibodies

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton.

list all antibodies Gene Name GeneID UniProt
SHANK1 50944 Q9Y566
SHANK1 78957 Q9WV48
SHANK1 243961 D3YZU1
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Top anti-SHANK1 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC, WB Shank1 Brain Membranes Western Blotting. 100 μg Log in to see 3 to 4 Days
$383.90
Details
Human Rabbit Un-conjugated IF (p), IHC (p)   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated IHC (fro), IF, IP, WB   0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse HRP IHC, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Human Mouse FITC IHC, WB   100 μg Log in to see 3 to 4 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) IHC, WB   100 μg Log in to see 3 to 4 Days
$429.00
Details
Human Mouse Biotin IHC, WB   100 μg Log in to see 3 to 4 Days
$431.20
Details
Human Mouse PE IHC, WB   100 μg Log in to see 3 to 4 Days
$432.30
Details
Human Mouse Streptavidin IHC, WB   100 μg Log in to see 3 to 4 Days
$433.40
Details
Human Mouse APC IHC, WB   100 μg Log in to see 3 to 4 Days
$434.50
Details

SHANK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SHANK1 Antibodies

  1. Human Monoclonal SHANK1 Primary Antibody for IHC, WB - ABIN863122 : Hung, Futai, Sala, Valtschanoff, Ryu, Woodworth, Kidd, Sung, Miyakawa, Bear, Weinberg, Sheng: Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 (PubMed)

  2. Human Polyclonal SHANK1 Primary Antibody for IF (p), IHC (p) - ABIN726335 : Zhang, Zheng, Wan, Shao, Liu, Zhang, Zhang: The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease. in Journal of controlled release : official journal of the Controlled Release Society 2014 (PubMed)

More Antibodies against SHANK1 Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) interaction partners

  1. Data show that the Shank1 protein mRNA 3' UTR (show UTS2R Antibodies) adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP (show FMR1 Antibodies)).

  2. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA

  3. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia.

  4. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning.

  5. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C (show KIF5C Antibodies) and the KIF5 (show KIF5A Antibodies)-associated RNA-binding protein (show PTBP1 Antibodies) staufen1 (show STAU1 Antibodies).

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) interaction partners

  1. "reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B (show SHANK3 Antibodies)-/- mice, was due to a reduction in Pvalb (show PVALB Antibodies) mRNA and PV protein

  2. Since mutations in all three human SHANK (show SHANK2 Antibodies) genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank (show SHANK2 Antibodies) mutant mice serve as corresponding in vivo model systems--{REVIEW}

  3. Results suggest that Shank1 scaffold in PV+ interneurons regulates excitatory synaptic strength and participates in the maintenance of excitatory and inhibitory balance in excitatory neurons.

  4. Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear.

  5. This study demonistrated that Shank1+/- heterozygous and to a lesser extent Shank1-/- null mutant mice displayed slightly elevated levels of self-grooming behavior as adults, but not as juveniles.

  6. These findings provide convincing evidence for Shank (show SHANK2 Antibodies) 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95 (show DLG4 Antibodies)/Shank 1 complexes at cone synapses in the outer retina.

  7. Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions.

  8. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.

  9. These results affirm the importance of Shank1 for synapse structure and function in vivo, and they highlight a differential role for Shank1 in specific cognitive processes.

  10. Semi-quantitative analysis of RNA levels in FMRP (show FMR1 Antibodies) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (show PSD Antibodies) components, such as Shank1, SAPAP1 (show DLGAP1 Antibodies)-3, PSD-95 (show DLG4 Antibodies), and the glutamate (show GRIN1 Antibodies) receptor subunits NR1 (show GRIN1 Antibodies) and NR2B (show GRIN2B Antibodies), are associated with FMRP (show FMR1 Antibodies).

SHANK1 Antigen Profile

Protein Summary

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene names and symbols associated with SHANK1

  • SH3 and multiple ankyrin repeat domains 1 (SHANK1) antibody
  • SH3 and multiple ankyrin repeat domains 1 (Shank1) antibody
  • SH3/ankyrin domain gene 1 (Shank1) antibody
  • Shank1a antibody
  • SPANK-1 antibody
  • Spank1 antibody
  • Sstrip antibody
  • synamon antibody

Protein level used designations for SHANK1

SH3 and multiple ankyrin repeat domains protein 1 , SSTR-interacting protein , somatostatin receptor-interacting protein , GKAP/SAPAP interacting protein , GKAP/SAPAP-interacting protein , SAPAP-interacting protein synamon , SH3/ankyrin domain gene 1 , SPANK-1 , synamon , SH3 and multiple ankyrin repeat domains 1

GENE ID SPECIES
50944 Homo sapiens
78957 Rattus norvegicus
484359 Canis lupus familiaris
100512353 Sus scrofa
518970 Bos taurus
243961 Mus musculus
Selected quality suppliers for anti-SHANK1 (SHANK1) Antibodies
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