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SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kits

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Additionally we are shipping SHANK1 Antibodies (85) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SHANK1 SHANK1 50944 Q9Y566
Anti-Rat SHANK1 SHANK1 78957 Q9WV48
Anti-Mouse SHANK1 SHANK1 243961 D3YZU1
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More ELISA Kits for SHANK1 Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) interaction partners

  1. Data show that the Shank1 protein mRNA 3' UTR (show UTS2R ELISA Kits) adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP (show FMR1 ELISA Kits)).

  2. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA

  3. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia.

  4. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning.

  5. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5 (show KIF5A ELISA Kits)-associated RNA-binding protein (show PTBP1 ELISA Kits) staufen1 (show STAU1 ELISA Kits).

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) interaction partners

  1. "reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B (show SHANK3 ELISA Kits)-/- mice, was due to a reduction in Pvalb (show PVALB ELISA Kits) mRNA and PV protein

  2. Since mutations in all three human SHANK (show SHANK2 ELISA Kits) genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank (show SHANK2 ELISA Kits) mutant mice serve as corresponding in vivo model systems--{REVIEW}

  3. Results suggest that Shank1 scaffold in PV+ interneurons regulates excitatory synaptic strength and participates in the maintenance of excitatory and inhibitory balance in excitatory neurons.

  4. Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear.

  5. This study demonistrated that Shank1+/- heterozygous and to a lesser extent Shank1-/- null mutant mice displayed slightly elevated levels of self-grooming behavior as adults, but not as juveniles.

  6. These findings provide convincing evidence for Shank (show SHANK2 ELISA Kits) 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95 (show DLG4 ELISA Kits)/Shank 1 complexes at cone synapses in the outer retina.

  7. Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions.

  8. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.

  9. These results affirm the importance of Shank1 for synapse structure and function in vivo, and they highlight a differential role for Shank1 in specific cognitive processes.

  10. Semi-quantitative analysis of RNA levels in FMRP (show FMR1 ELISA Kits) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (show PSD ELISA Kits) components, such as Shank1, SAPAP1 (show DLGAP1 ELISA Kits)-3, PSD-95 (show DLG4 ELISA Kits), and the glutamate (show GRIN1 ELISA Kits) receptor subunits NR1 (show GRIN1 ELISA Kits) and NR2B (show GRIN2B ELISA Kits), are associated with FMRP (show FMR1 ELISA Kits).

SHANK1 Antigen Profile

Antigen Summary

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene names and symbols associated with SHANK1

  • SH3 and multiple ankyrin repeat domains 1 (SHANK1) antibody
  • SH3 and multiple ankyrin repeat domains 1 (Shank1) antibody
  • SH3/ankyrin domain gene 1 (Shank1) antibody
  • Shank1a antibody
  • SPANK-1 antibody
  • Spank1 antibody
  • Sstrip antibody
  • synamon antibody

Protein level used designations for SHANK1

SH3 and multiple ankyrin repeat domains protein 1 , SSTR-interacting protein , somatostatin receptor-interacting protein , GKAP/SAPAP interacting protein , GKAP/SAPAP-interacting protein , SAPAP-interacting protein synamon , SH3/ankyrin domain gene 1 , SPANK-1 , synamon , SH3 and multiple ankyrin repeat domains 1

GENE ID SPECIES
50944 Homo sapiens
78957 Rattus norvegicus
484359 Canis lupus familiaris
100512353 Sus scrofa
518970 Bos taurus
243961 Mus musculus
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