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SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) ELISA Kits

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Additionally we are shipping SHANK2 Antibodies (141) and SHANK2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SHANK2 SHANK2 22941 Q9UPX8
Anti-Rat SHANK2 SHANK2 171093 Q9QX74
Anti-Mouse SHANK2 SHANK2 210274 Q80Z38
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More ELISA Kits for SHANK2 Interaction Partners

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. variants in the SHANK2 gene in a schizophrenia patient cohort

  2. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (show CFTR ELISA Kits).

  3. syndapin I (show PACSIN1 ELISA Kits) functions reflected direct, SH3 domain (show ITSN1 ELISA Kits)-mediated associations and functional interactions with ProSAP1/Shank2.

  4. Lack of association between NLGN3 (show NLGN3 ELISA Kits), NLGN4 (show NLGN4X ELISA Kits), SHANK2 and SHANK3 (show SHANK3 ELISA Kits) gene variants and autism spectrum disorder in a Chinese population.

  5. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate (show GRIN1 ELISA Kits) receptors at the synapse and increased levels of ProSAP2/Shank3 (show SHANK3 ELISA Kits)

  6. we confirmed that de novo SHANK2 deletions are present in patients with ASD (show ARSD ELISA Kits) and showed that several SHANK2 variants reduce the number of synapses in vitro

  7. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (show ARSD ELISA Kits)

  8. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD (show ARSD ELISA Kits)) and mental retardation

  9. betaPix (show ARHGEF7 ELISA Kits) up-regulates NHE3 (show SLC9A3 ELISA Kits) membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells

  10. Shank2 increased the membrane expression and basal activity of NHE3 (show SLC9A3 ELISA Kits) and attenuated the cAMP-dependent inhibition of NHE3 (show SLC9A3 ELISA Kits) activity.

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) interaction partners

  1. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1 (show TBR1 ELISA Kits)+/- mice

  2. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  3. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  4. syndapin I (show PACSIN1 ELISA Kits) functions reflected direct, SH3 domain (show ITSN1 ELISA Kits)-mediated associations and functional interactions with ProSAP1/Shank2.

  5. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

  6. Shank2 negatively regulates CFTR (show CFTR ELISA Kits) and this may play a significant role in maintaining epithelial homeostasis

  7. Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina.

SHANK2 Antigen Profile

Antigen Summary

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Gene names and symbols associated with SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2) antibody
  • SH3/ankyrin domain gene 2 (shank2) antibody
  • SH3 and multiple ankyrin repeat domains 2 (LOC100338286) antibody
  • SH3 and multiple ankyrin repeat domains 2 (Shank2) antibody
  • SH3 and multiple ankyrin repeat domains 2 (shank2) antibody
  • SH3/ankyrin domain gene 2 (Shank2) antibody
  • auts17 antibody
  • cortbp1 antibody
  • cttnbp1 antibody
  • MGC122482 antibody
  • mKIAA1022 antibody
  • prosap1 antibody
  • SHANK antibody
  • SHANK2 antibody
  • spank-3 antibody

Protein level used designations for SHANK2

SH3 and multiple ankyrin repeat domains 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , GKAP/SAPAP-interacting protein , SH3/ankyrin domain gene 2 , proline rich synapse associated protein 1 , cortBP1

GENE ID SPECIES
428858 Gallus gallus
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
466694 Pan troglodytes
708192 Macaca mulatta
747845 Pan troglodytes
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
22941 Homo sapiens
171093 Rattus norvegicus
483677 Canis lupus familiaris
618649 Bos taurus
734458 Xenopus laevis
210274 Mus musculus
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