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SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) ELISA Kits

SHANK3 is a member of the Shank gene family. Additionally we are shipping SHANK3 Antibodies (94) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SHANK3 85358 Q9BYB0
Anti-Rat SHANK3 SHANK3 59312 Q9JLU4
Anti-Mouse SHANK3 SHANK3 58234 Q4ACU6
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Top SHANK3 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 3.9pg/ml 15.6-1000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for SHANK3 Interaction Partners

Zebrafish SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

Human SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7, miR (show MLXIP ELISA Kits)-34a, and miR (show MLXIP ELISA Kits)-504, is reported.

  2. these data suggest that SHANK3 mutations predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to pharmacological intervention.

  3. De novo SHANK3 mutation causes Rett syndrome-like phenotype in a female patient.

  4. miR-7 binds to 3-prime untranslated regions of SHANK3 mRNA and causes the alteration of neuronal morphology and function, potentially playing a crucial role in the pathophysiological process of schizophrenia

  5. a mutation in SHANK3 that underscores its relevance in Autism Spectrum Disorder.

  6. This study identified and confirmed SHANK3 protein changes within the postsynaptic density in schizophrenia

  7. because the deletions in our patients do not involve the SHANK3 gene, we posit the existence of a new contiguous gene syndrome proximal to the smallest terminal deletions in the 22q13 region.

  8. This study is the first to identify specific chromosome 22q13.2q13.32 genomic regions, in addition to the terminal 22q13.33 genomic region encompassing SHANK3, associated with key phenotypes in Phelan-McDermid syndrome.

  9. The ability to alter the epigenetic modification and expression of SHANK3 by environmental factors suggests that SHANK3 may be a valuable biomarker for dissecting the role of gene and environment interaction in the etiology of ASD (show ARSD ELISA Kits).

  10. our results suggested that this commonly genetic variant in SHANK3 gene strikingly decreased the risk of ism spectrum disorder in China.

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. Cortical neurons cultured on MEAs displayed a rich repertoire of spontaneous firing, and Shank3 deletion led to reduced firing. MEA (show MEA1 ELISA Kits) recordings revealed electric phenotypes that displayed altered excitation and inhibition in the network lacking Shank3.

  2. "reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1 (show SHANK1 ELISA Kits)-/- and Shank3B-/- mice, was due to a reduction in Pvalb (show PVALB ELISA Kits) mRNA and PV protein.

  3. post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7, miR (show MLXIP ELISA Kits)-34a, and miR (show MLXIP ELISA Kits)-504, is reported.

  4. differential Shank3 mRNA stability and SHANK1 (show SHANK1 ELISA Kits)/2 upregulation in mutant mice with Shank3 mutations linked to autism spectrum disorder and schizophrenia

  5. social deficits and NMDAR (show GRIN1 ELISA Kits) hypofunction are rescued by inhibiting cofilin (show CFL1 ELISA Kits) or activating Rac1 in Shank3-deficient mice

  6. results reveal the profound effect of post-developmental activation of Shank3 expression on neural function, and demonstrate a certain degree of continued plasticity in the adult diseased brain

  7. Since mutations in all three human SHANK (show SHANK2 ELISA Kits) genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank (show SHANK2 ELISA Kits) mutant mice serve as corresponding in vivo model systems--{REVIEW}

  8. This study demonstrated that Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits in mice.

  9. results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain-independent

  10. prenatal zinc deficiency as a risk factor for autism spectrum disorder may unfold through the deregulation of zinc-binding ProSAP/Shank (show SHANK2 ELISA Kits) family members

SHANK3 Antigen Profile

Antigen Summary

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

Gene names and symbols associated with SHANK3

  • SH3 and multiple ankyrin repeat domains 3 (SHANK3) antibody
  • SH3 and multiple ankyrin repeat domains protein 3 (shank3) antibody
  • SH3 and multiple ankyrin repeat domains 3 (Shank3) antibody
  • SH3/ankyrin domain gene 3 (Shank3) antibody
  • AI841104 antibody
  • DEL22q13.3 antibody
  • Prosap2 antibody
  • PSAP2 antibody
  • SCZD15 antibody
  • Shank3b antibody
  • SPANK-2 antibody

Protein level used designations for SHANK3

SH3 and multiple ankyrin repeat domains 3 , SH3 and multiple ankyrin repeat domains protein 3-like , SH3 and multiple ankyrin repeat domains protein 3 , proline rich synapse associated protein 2 , shank postsynaptic density protein , SH3/ankyrin domain gene 3 , SPANK-2 , Shank postsynaptic density protein 3a , proline-rich synapse-associated protein 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 1 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 3 , SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1 , proSAP2

GENE ID SPECIES
100056993 Equus caballus
100447919 Pongo abelii
100482495 Ailuropoda melanoleuca
793484 Danio rerio
85358 Homo sapiens
59312 Rattus norvegicus
474456 Canis lupus familiaris
512428 Bos taurus
58234 Mus musculus
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