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anti-SH3 and PX Domains 2A (SH3PXD2A) Antibodies

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH3PXD2A 9644 Q5TCZ1
SH3PXD2A 14218 O89032
SH3PXD2A    
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Top anti-SH3PXD2A Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in Hela cell line lysates (35ug/lane) using SH3PXD2A Antibody (N-term) Cat.-No AP53904PU-N.This demonstrates the SH3PXD2A antibody detected the SH3PXD2A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SH3PXD2A Antibody (N-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SH3PXD2A antibody detected the SH3PXD2A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC (p) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Goat Un-conjugated IHC (p) 50 μg Log in to see 11 to 13 Days
$541.80
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

SH3PXD2A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SH3PXD2A Antibodies

  1. Human Polyclonal SH3PXD2A Primary Antibody for EIA, WB - ABIN954793 : Crimaldi, Courtneidge, Gimona: Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation. in Experimental cell research 2009 (PubMed)
    Show all 2 references for ABIN954793

More Antibodies against SH3PXD2A Interaction Partners

Human SH3 and PX Domains 2A (SH3PXD2A) interaction partners

  1. Results suggest that Tks5, similar to XB130 (show AFAP1L2 Antibodies), plays a role in cell proliferation and cell survival and that the interaction between XB130 (show AFAP1L2 Antibodies) and Tks5 appears to be critical for regulation of Src (show SRC Antibodies)-mediated cellular homeostasis.

  2. TKS5 and MYLK (show MYLK Antibodies) represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1 (show ZEB1 Antibodies)/miR (show MLXIP Antibodies)-200 feedback loop

  3. establishes an important role for Tks5 in tumor growth in vivo, and suggests that invadopodia may play broad roles in tumor progression

  4. Results show that TKS5 is highly expressed in many cancer types with strong correlation with increased metastatic events and a poorer prognosis suggesting a clinical importance.

  5. Inhibiting the function of Tks5 both reduced extracellular matrix degradation in vitro and disrupted motoneuron axons from exiting the spinal cord and extending into the periphery.

  6. Tks5 is needed for breast carcinoma cell invadopodium precursor stabilization, where the phox homology (PX) domain of Tks5 interacts with PI(3,4)P2. SHIP2 (show INPPL1 Antibodies) arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation.

  7. Src (show SRC Antibodies)-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells.

  8. Genes including LEP (show LEP Antibodies) and SH3PXD2A were differentially expressed (p<0.05 and fold change >1.5) in pre-eclampsia placentas.

  9. high Tks5long and low Tks5short expressions in human lung adenocarcinomas correlated with metastatic disease and predicted worse survival of early stage patients

  10. Tks5, a master regulator of invadopodia in cancer cells, is crucial for osteoclast fusion downstream of phosphoinositide 3-kinase and Src (show SRC Antibodies).

Mouse (Murine) SH3 and PX Domains 2A (SH3PXD2A) interaction partners

  1. Results show that TKS5 is highly expressed in many cancer types with strong correlation with increased metastatic events and a poorer prognosis suggesting a clinical importance.

  2. Signaling leading to Tks5 activation in peritoneal mesothelial cells may be a suitable therapeutic target for prevention of peritoneal carcinomatosis.

  3. Tks5 undergoes an isoform switch during metastatic progression in a genetically engineered mouse model of lung adenocarcinoma

  4. Tks5, a master regulator of invadopodia in cancer cells, is crucial for osteoclast fusion downstream of phosphoinositide 3-kinase and Src (show SRC Antibodies).

  5. Src (show SRC Antibodies)-Tks5 pathway is required for neural crest cell migration during embryonic development

  6. Examination of the initial stages of podosome formation has revealed an important role for the phosphoinositide PI(3,4)P(2) in anchoring the scaffold protein (show HOMER1 Antibodies) Tks5 to the plasma membrane.

  7. Data suggest that Src (show SRC Antibodies)-dependent phosphorylation of beta-dystroglycan results in the formation of a Src (show SRC Antibodies)/dystroglycan (show DAG1 Antibodies) complex that drives the SH3-mediated association between dystroglycan (show DAG1 Antibodies) and Tks5 which together regulate podosome formation in myoblasts.

  8. The tandem SH3A and SH3B domains of Tks5 constitute a versatile module for the implementation of isoform-specific protein-protein interactions.

  9. Tks5 facilitates the production of ROS (show ROS1 Antibodies) necessary for invadopodia formation, and in turn ROS (show ROS1 Antibodies) modulate Tks5 tyrosine phosphorylation in a positive feedback loop.

Zebrafish SH3 and PX Domains 2A (SH3PXD2A) interaction partners

  1. Src (show SRC Antibodies)-Tks5 pathway is required for neural crest cell migration during embryonic development [TKS5]

SH3PXD2A Antigen Profile

Protein Summary

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (By similarity).

Gene names and symbols associated with SH3PXD2A

  • SH3 and PX domains 2A (SH3PXD2A) antibody
  • SH3 and PX domains 2A (Sh3pxd2a) antibody
  • SH3 and PX domains 2Aa (sh3pxd2aa) antibody
  • 2310014D11Rik antibody
  • AA589508 antibody
  • AI256723 antibody
  • AI413738 antibody
  • C230050L11 antibody
  • EG329070 antibody
  • Fish antibody
  • Gm5098 antibody
  • Sh3md1 antibody
  • sh3pxd2a antibody
  • si:dkey-82d4.2 antibody
  • Tks5 antibody
  • TSK5 antibody

Protein level used designations for SH3PXD2A

SH3 and PX domain-containing protein 2A , SH3 multiple domains 1 , adapter protein TKS5 , adaptor protein TKS5 , five SH3 domain-containing protein , tyrosine kinase substrate with five SH3 domains , SH3 multiple domains protein 1 , five SH3 domains , SH3 and PX domains 2A , Tks5

GENE ID SPECIES
9644 Homo sapiens
14218 Mus musculus
562018 Danio rerio
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