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anti-SH3 and PX Domains 2B (SH3PXD2B) Antibodies

SH3PXD2B encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. Additionally we are shipping SH3 and PX Domains 2B Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH3PXD2B 285590 A1X283
SH3PXD2B 268396 A2AAY5
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Top anti-SH3 and PX Domains 2B Antibodies at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated ICC, IP, WB 100 μg Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IP, WB 100 μg Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 8 to 10 Days
$595.83
Details
Mouse Rabbit Un-conjugated IC, IP, WB 100 μg Log in to see 11 to 16 Days
$603.43
Details

SH3PXD2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,


Mouse (Murine)


More Antibodies against SH3 and PX Domains 2B Interaction Partners

Human SH3 and PX Domains 2B (SH3PXD2B) interaction partners

  1. Misfolded Frank-ter (show TECR Antibodies) Haar syndrome protein Tks4(R43W) is transported via the microtubule system to the aggresomes.

  2. a new function for Tks4 in the regulation of growth factor-dependent cell migration.

  3. SH3PXD2B is a scaffold protein (show HOMER1 Antibodies) that plays a key role in regulating the actin cytoskeleton via Src (show SRC Antibodies) and cortactin (show CTTN Antibodies).

  4. Tks4 and Tks5 (show SH3PXD2A Antibodies) directly bind to NoxA1 (show NOXA1 Antibodies). The integrity of the N-terminal PRR (show PVRL1 Antibodies) of NoxA1 (show NOXA1 Antibodies) is essential for this direct interaction with the Tks (show PTK6 Antibodies) proteins.

  5. The Nox1 (show NOX1 Antibodies)-dependent generation of reactive oxygen species is dependent on Src (show SRC Antibodies) phosphorylation of NoxA1 (show NOXA1 Antibodies) and Tks4. Blockage of phosphorylation of NoxA1 (show NOXA1 Antibodies) and Tks4 decreases Nox1 (show NOX1 Antibodies)-dependent ROS (show ROS1 Antibodies) generation and blocks SrcYF-induced invadopodia formation.

  6. These findings establish a role for TKS4 in Frank-Ter (show TECR Antibodies) Haar syndrome and embryonic development.

Mouse (Murine) SH3 and PX Domains 2B (SH3PXD2B) interaction partners

  1. eyes of B10-Sh3pxd2bnee mice exhibit multiple features of congenital glaucoma.

  2. The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) mirrors craniofacial dysmorphology and otitis media in humans.

  3. These findings establish a role for TKS4 in Frank-Ter (show TECR Antibodies) Haar syndrome and embryonic development.

  4. SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development.

  5. Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells.

  6. Tks4 has a role in the formation and function of podosomes.

  7. Silencing of C/EBPdelta (show CEBPD Antibodies) impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis.

SH3 and PX Domains 2B (SH3PXD2B) Antigen Profile

Protein Summary

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome.

Gene names and symbols associated with SH3PXD2B

  • SH3 and PX domains 2B (SH3PXD2B) antibody
  • SH3 and PX domains 2B (Sh3pxd2b) antibody
  • fad49 antibody
  • FTHS antibody
  • G431001E03Rik antibody
  • HOFI antibody
  • KIAA1295 antibody
  • TKS4 antibody
  • TSK4 antibody

Protein level used designations for SH3PXD2B

SH3 and PX domain-containing protein 2B , adapter protein HOFI , adaptor protein HOFI , factor for adipocyte differentiation 49 , tyrosine kinase substrate with four SH3 domains

GENE ID SPECIES
285590 Homo sapiens
268396 Mus musculus
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