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anti-SH3-Domain Binding Protein 2 (SH3BP2) Antibodies

The protein encoded by SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. Additionally we are shipping SH3-Domain Binding Protein 2 Proteins (5) and SH3-Domain Binding Protein 2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH3BP2 6452 P78314
SH3BP2 24055  
SH3BP2 305450  
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Top anti-SH3-Domain Binding Protein 2 Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis using SH3BP2 Antibody (Center) Cat.-No AP53901PU-N in Mouse spleen tissue lysates (35ug/lane).This demonstrates the SH3BP2 antibody detected the SH3BP2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Sheep Un-conjugated WB 0.25 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA Western blot analysis is shown using anti-SH3BP2 pS427 antibody to detect endogenous protein present in unstimulated human whole cell lysates). The band as indicated by the arrowheads is evident in both M059 cells (panel A) and PC-3 cells (panel B). Comparison to a molecular weight marker indicates a band of ~60 kDa corresponding to human SH3BP2 protein. The blot was incubated with a 1:500 dilution of the antibody at room temperature followed by detection using standard techniques. Personal communication Steven Pelech, Kinexus Inc. 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Liver, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Kidney, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated WB SH3BP2 Antibody (Center)  western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the SH3BP2 antibody detected the SH3BP2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis is shown using Affinity Purified anti-SH3BP2 pS427 antibody to detect endogenous protein present in unstimulated human whole cell lysates).  The band as indicated by the arrowheads is evident in both M059 cells (panel A) and PC-3 cells (panel B).  Comparison to a molecular weight marker indicates a band of ~60 kDa corresponding to human SH3BP2 protein.  The blot was incubated with a 1:500 dilution of the antibody at room temperature followed by detection using standard techniques.  100 μg Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$610.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SH3BP2 on A-431 cell (antibody concentration 20 µg/mL). SH3BP2 monoclonal antibody (M01), clone 1E9 Western Blot analysis of SH3BP2 expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

SH3BP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
,
,
, , , , ,
Mouse (Murine)
,

Rat (Rattus)


Top referenced anti-SH3-Domain Binding Protein 2 Antibodies

  1. Human Polyclonal SH3BP2 Primary Antibody for EIA - ABIN118009 : Imai, Kanno, Moriya, Kayano, Seino, Matsubara, Yamada: A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism. in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2003 (PubMed)
    Show all 6 references for ABIN118009

  2. Human Polyclonal SH3BP2 Primary Antibody for EIA, WB - ABIN954791 : Lietman, Yin, Levine: SH3BP2 mutations potentiate osteoclastogenesis via PLCγ. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010 (PubMed)
    Show all 3 references for ABIN954791

  3. Mouse (Murine) Polyclonal SH3BP2 Primary Antibody for WB - ABIN264981 : Songyang, Shoelson, McGlade, Olivier, Pawson, Bustelo, Barbacid, Sabe, Hanafusa, Yi: Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. in Molecular and cellular biology 1994 (PubMed)
    Show all 2 references for ABIN264981

  4. Chicken Polyclonal SH3BP2 Primary Antibody for IHC, WB - ABIN2786764 : Idowu, Thomas, Frow, Diss, Flanagan: Mutations in SH3BP2, the cherubism gene, were not detected in central or peripheral giant cell tumours of the jaw. in The British journal of oral & maxillofacial surgery 2008 (PubMed)

More Antibodies against SH3-Domain Binding Protein 2 Interaction Partners

Human SH3-Domain Binding Protein 2 (SH3BP2) interaction partners

  1. The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.

  2. A c.1244G>A (p.Arg415Gln) mutation in SH3BP2 gene causes cherubism in a Turkish family

  3. Authors conclude that a novel p.Asp419Tyr alteration in SH3BP2 to be a cherubism-causing mutation in a Turkish family.

  4. In the first family, a missense mutation Arg415Gln was found in exon 9 of SH3BP2 in all affected individuals. The unaffected individuals did not have the mutation. In the second family, a missense mutation Pro418Thr was identified in exon 9 of the SH3BP2

  5. These results demonstrate that PARP1 (show PARP1 Antibodies) regulates expression of SH3BP2.

  6. P416R mutation of 3BP2 causes the gain of function in B cells by increasing the interaction with specific signaling molecules.

  7. if a primary genetic defect is the cause for CGCG it is either located in SH3BP2 gene exons not yet related to cherubism or in a different gene.

  8. The SH-3BP-2 mutation may participate in the differentiation and maturation of osteoclast-like cells in the lesion of cherubism.

  9. over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 (show PLCG1 Antibodies) and PLCgamma2 (show PLCG2 Antibodies).

  10. No SH3BP2 gene mutation was found in PGCL.

Mouse (Murine) SH3-Domain Binding Protein 2 (SH3BP2) interaction partners

  1. Bone marrow transplantation also ameliorated the inflammation and bone loss in 10-week-old Sh3bp2(knock in) mice.

  2. These findings suggest that the SH3BP2 cherubism mutation can cause jawbone destruction by promoting osteoclast formation in response to TNF-alpha (show TNF Antibodies) expressed in cherubism lesions and that SH3BP2 is a key regulator for TNF-alpha (show TNF Antibodies)-induced osteoclastogenesis

  3. 3BP2 was needed for LPS (show TLR4 Antibodies)-induced activation of macrophage signaling pathways. Having a single Sh3bp2 Gly418Arg allele and PAMP (show ADM Antibodies) stimulation had a cooperative effect on macrophage activation and inflammatory responses.

  4. Phosphorylation of SH3BP2 at Y183 is critical for the TNF-alpha (show TNF Antibodies) production.

  5. Gain-of-function of SH3BP2 augments inflammation and bone loss in the CIA (show NCOA5 Antibodies) model through increased macrophage activation and osteoclast formation.

  6. Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-alpha (show TNF Antibodies)-induced inflammation and bone loss.

  7. By participating in FcepsilonRI (show FCER1A Antibodies)-mediated signal transduction, 3BP2 is an important regulator of human mast cell activation.

  8. Adapter protein (show GRB10 Antibodies) 3BP2 links chemoattractant fMLF-induced receptor signaling events to neutrophil actin cytoskeleton and NADPH oxidase (show NOX1 Antibodies) complex, a requirement for effective bactericidal function in vivo.

  9. Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.

  10. Data provide evidence for a concerted HIF-1alpha (show HIF1A Antibodies)/MT1-MMP (show MMP14 Antibodies) signalling axis that explains the induction of adaptor protein 3BP2 and which may link protein (show HAPLN1 Antibodies) binding partners together and stimulate oncogenic MSC (show MSC Antibodies) migration.

SH3-Domain Binding Protein 2 (SH3BP2) Antigen Profile

Protein Summary

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH3BP2

  • SH3-domain binding protein 2 (SH3BP2) antibody
  • SH3-domain binding protein 2 (Sh3bp2) antibody
  • 3BP-2 antibody
  • 3BP2 antibody
  • CRBM antibody
  • CRPM antibody
  • SH3BP2 antibody

Protein level used designations for SH3BP2

SH3-domain binding protein 2 , SH3 domain-binding protein 2 , Abl-SH3 binding protein 2 , TNFAIP3 interacting protein 2 , 3BP-2

GENE ID SPECIES
100051380 Equus caballus
617344 Bos taurus
6452 Homo sapiens
24055 Mus musculus
305450 Rattus norvegicus
488797 Canis lupus familiaris
422883 Gallus gallus
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