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may bind c-Jun N-terminal kinase (JNK); may play a role in JNK and Bruton's tyrosine kinase (Btk) mediated signaling pathways. Additionally we are shipping SH3-Domain Binding Protein 5 (BTK-Associated) Proteins (7) and SH3-Domain Binding Protein 5 (BTK-Associated) Kits (3) and many more products for this protein.
Showing 10 out of 34 products:
Human Monoclonal SH3BP5 Primary Antibody for IF, IHC (p) - ABIN564087
Win, Than, Fernandez-Checa, Kaplowitz: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. in Cell death & disease 2014
REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11.
The interplay of p-JNK (show MAPK8 Antibodies) with mitochondrial Sab leads to impaired respiration, ROS (show ROS1 Antibodies) production, sustained JNK (show MAPK8 Antibodies) activation, and apoptosis.
SH3BP5 binds to JNK (show MAPK8 Antibodies) and directly inhibits JNK (show MAPK8 Antibodies) through its two putative mitogen-activated protein kinase (show MAPK1 Antibodies) interaction motifs (KIMs).
mitochondrial protein (show COX6B2 Antibodies) Sab is phosphorylated by stress-activated protein kinase 3 (show MAPK12 Antibodies)
The binding to and phosphorylation of Sab by p-JNK (show MAPK8 Antibodies) on the outer mitochondrial membrane leads to SHP1 (show PTPN6 Antibodies)-dependent and DOK4 (show DOK4 Antibodies)-dependent inactivation of p-Src (show SRC Antibodies) on the inner membrane; inactivation of mitochondrial Src (show SRC Antibodies) inhibits electron transport and increases reactive oxygen species release, which sustains JNK (show MAPK8 Antibodies) activation and promotes cell death and organ injury.
ER stress triggers an interaction of JNK (show MAPK8 Antibodies) with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
JNK (show MAPK8 Antibodies)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF (show TNF Antibodies)) requires mitochondrial Sab protein expression in mice
may bind c-Jun N-terminal kinase (JNK)\; may play a role in JNK and Bruton's tyrosine kinase (Btk) mediated signaling pathways
SH3 domain-binding protein 5
, SH3 domain-binding protein that preferentially associates with BTK
, vascular endothelial cell-specific protein 18