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directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank. Additionally we are shipping and SHARPIN Kits (4) and many more products for this protein.
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Study identifies a role for SHARPIN in TCR signaling whereby it maintains immunological homeostasis and tolerance by regulating Treg cells.
severity of the esophagitis was not affected by crossing SHARPIN-deficient mice with lymphocyte-deficient Rag1 (show RAG1 Antibodies) null mice
Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.
Data indicate that genetic ablation of caspase-1 (show CASP1 Antibodies) and -11 from cpdm mice significantly reduced skin inflammation in sharpin-deficient mice.
Our results suggest that SHARPIN plays a significant role in skeletal homeostasis and that this role is strongly regulated through TNF (show TNF Antibodies) pathways.
Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF (show TNF Antibodies)-induced apoptosis.
Tnfr1 (show TNFRSF1A Antibodies), but not Tnfr2 (show TNFRSF1B Antibodies), deficiency suppresses inflammation in sharpin deficient mice.
SHARPIN is required for optimal NLRP3 (show NLRP3 Antibodies) inflammasome activation.
Sharpin deficiency results in chronic proliferative dermatitis/ autoinflammatory disease in the absence of B and T lymphocytes and IL4 (show IL4 Antibodies)/IL13 (show IL13 Antibodies) signaling.
SHARPIN controls lymphocyte migration by endogenously maintaining LFA-1 (show ITGAL Antibodies) inactive to allow adjustable detachment of the uropods in polarized cells.
Data show that SHANK-associated RH domain interacting protein (SHARPIN) gene expression in breast cancer patients predicts clinical outcomes.
the roles of SHARPIN in inhibiting integrin activity and supporting linear ubiquitination are (molecularly) distinct.
progesterone significantly reduced SIPL1 mRNA and protein expression in MCF7 cells. As progesterone enhances breast cancer tumorigenesis in context dependent manner, inhibition of SIPL1 expression may contribute to progesterone's non-tumorigenic function
SIPL1 binds PTEN (show PTEN Antibodies) and enhances PTEN (show PTEN Antibodies) polyubiquitination.
SIPL1 promotes AKT (show AKT1 Antibodies) activation by decreasing the amount of PTEN (show PTEN Antibodies) protein in CHO (show COL11A1 Antibodies)-K1 cells.
crystals of SHARPIN belonged to the primitive tetragonal space group P4(3)2(1)2, with unit-cell parameters a = b = 61.55, c = 222.81 A
the crystal structure of the N-terminal portion of SHARPIN, which adopts the highly conserved pleckstrin (show PLEK Antibodies) homology superfold that is often used as a scaffold to create protein interaction modules
SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations.
directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank
, protein kinase C-interacting protein RBCC like 1
, shank-associated RH domain-interacting protein
, shank-interacting protein-like 1
, SHANK-associated RH domain interacting protein
, shank-interacting protein