anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) Antibodies

directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank. Additionally we are shipping and SHARPIN Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SHARPIN 106025 Q91WA6
SHARPIN 81858 Q9H0F6
SHARPIN 81859 Q9EQL9
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Top anti-SHARPIN Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: CHAD Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml WB Suggested Anti-SHARPIN Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SHARPIN Antibody (Center)  western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the SHARPIN antibody detected the SHARPIN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: SHARPIN Antibody [NBP1-92386] - Staining of human colon shows strong cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SHARPIN Antibody [NBP1-92386] - Staining of human cell line MCF7 shows positivity in nucleus & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

SHARPIN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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More Antibodies against SHARPIN Interaction Partners

Mouse (Murine) SHANK-Associated RH Domain Interacting Protein (SHARPIN) interaction partners

  1. LUBAC components control TLR3 (show TLR3 Antibodies)-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.

  2. Suppression of SHARPIN impaired cell proliferation, angiogenesis, and invasion and reduced levels of MMP-9 in P (show EPHB2 Antibodies)rost (show AKT1 Antibodies)ate cancer cells and reduced the size of Metastatic Lung tumors induced by these cells in mice.

  3. Together, these data imply that SHARPIN regulates the normal invasive mammary gland branching morphogenesis in an epithelial cell extrinsic manner by controlling the organisation of the stromal extracellular matrix.

  4. Study found that the NZF (show PHF20 Antibodies) domain of SHARPIN, but not that of HOIL-1L (show RBCK1 Antibodies), is critical for effective protection from programmed cell death by enhancing the recruitment of the linear ubiquitin chain assembly complex to the activated TNFR (show TNFRSF1A Antibodies) complex. The binding activity to K63-linked ubiquitin chains that the NZF (show PHF20 Antibodies) domain of SHARPIN, but not that of HOIL-1L (show RBCK1 Antibodies), possesses appears to be involved in the recruitment.

  5. this study reveals a critical function of SHARPIN in TCR-induced NF-kappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies) signalling and thymic Treg cell generation

  6. SHARPIN-deficient mice develop a chronic proliferative dermatitis presenting angiogenesis and lymphatic dilatation.

  7. Study identifies a role for SHARPIN in TCR signaling whereby it maintains immunological homeostasis and tolerance by regulating Treg cells.

  8. severity of the esophagitis was not affected by crossing SHARPIN-deficient mice with lymphocyte-deficient Rag1 (show RAG1 Antibodies) null mice

  9. Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.

  10. Data indicate that genetic ablation of caspase-1 (show CASP1 Antibodies) and -11 from cpdm mice significantly reduced skin inflammation in sharpin-deficient mice.

Human SHANK-Associated RH Domain Interacting Protein (SHARPIN) interaction partners

  1. LUBAC components control TLR3 (show TLR3 Antibodies)-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.

  2. Overexpression of SHARPIN in Prostate cancer cells promoted cell growth and reduced apoptosis through NF-kB/ERK (show EPHB2 Antibodies)/Akt (show AKT1 Antibodies) pathway and apoptosis-associated proteins. SHARPIN enhances the metastasis of prostate cancer and impair patient survivals.

  3. Our study firstly identifies the role of SHARPIN in promoting wild-type P53 (show TP53 Antibodies) degradation and correlates with poor prognosis in P53 (show TP53 Antibodies) wild-type breast cancer.

  4. Data show that SHANK-associated RH domain interacting protein (SHARPIN) gene expression in breast cancer patients predicts clinical outcomes.

  5. the roles of SHARPIN in inhibiting integrin activity and supporting linear ubiquitination are (molecularly) distinct.

  6. progesterone significantly reduced SIPL1 mRNA and protein expression in MCF7 cells. As progesterone enhances breast cancer tumorigenesis in context dependent manner, inhibition of SIPL1 expression may contribute to progesterone's non-tumorigenic function

  7. SIPL1 binds PTEN (show PTEN Antibodies) and enhances PTEN (show PTEN Antibodies) polyubiquitination.

  8. Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF (show TNF Antibodies)-induced apoptosis.

  9. SIPL1 promotes AKT (show AKT1 Antibodies) activation by decreasing the amount of PTEN (show PTEN Antibodies) protein in CHO (show COL11A1 Antibodies)-K1 cells.

  10. SHARPIN controls lymphocyte migration by endogenously maintaining LFA-1 (show ITGAL Antibodies) inactive to allow adjustable detachment of the uropods in polarized cells.

SHARPIN Antigen Profile

Protein Summary

directly interacts with the ankyrin repeats of Shank; may be involved in regulating the function of Shank

Gene names and symbols associated with SHARPIN

  • SHANK-associated RH domain interacting protein (Sharpin) antibody
  • SHANK-associated RH domain interactor (SHARPIN) antibody
  • SHANK-associated RH domain interactor (Sharpin) antibody
  • 0610041B22Rik antibody
  • AW121341 antibody
  • Conneck1 antibody
  • cpdm antibody
  • RBCKL1 antibody
  • SIPL1 antibody

Protein level used designations for SHARPIN

mSIPL1 , protein kinase C-interacting protein RBCC like 1 , shank-associated RH domain-interacting protein , shank-interacting protein-like 1 , sharpin , hSIPL1 , SHANK-associated RH domain interacting protein , shank-interacting protein

GENE ID SPECIES
106025 Mus musculus
81858 Homo sapiens
81859 Rattus norvegicus
512499 Bos taurus
475122 Canis lupus familiaris
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