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May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. Additionally we are shipping SHCBP1 Antibodies (26) and and many more products for this protein.
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Immunohistochemical analysis revealed SHCBP1 was significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (82 of 128, 64%). Over-expressed SHCBP1 was correlated with advanced clinical stage and poorer survival. Ablation of SHCBP1 inhibited the proliferation in vitro.
Knockdown of SHCBP1 induced cell cycle delay.
The central region of SHCBP1 was found to bind to measles virus C protein (show HNRNPC PLURAL_@39359@), as well as the phosphoprotein, but the two viral proteins did not compete for SHCBP1 binding.
These data suggest that despite the striking upregulation of Shcbp1 during T cell proliferation, loss of Shcbp1 does not directly affect T cell development, but regulates CD4 (show CD4 Proteins)(+) T cell effector function in vivo.
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc (By similarity).
SHC SH2 domain-binding protein 1
, SHC-binding protein
, protein expressed in activated lymphocytes