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Acts as a transcriptional repressor. Additionally we are shipping SIN3 Transcription Regulator Homolog B (Yeast) Proteins (4) and many more products for this protein.
Showing 10 out of 52 products:
Mouse (Murine) Polyclonal SIN3B Primary Antibody for WB - ABIN2779895
Nomura, Uda-Tochio, Murai, Mori, Nishimura: The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. in Journal of molecular biology 2005
Cow (Bovine) Polyclonal SIN3B Primary Antibody for WB - ABIN2784243
Dhanda, Lindberg, Olsson: The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. in BMC molecular biology 2008
these results suggest that stress-induced Sin3B activation is p53 (show TP53 Antibodies)-dependent and is essential for p53 (show TP53 Antibodies)-mediated repression of its selective target genes.
The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners.
A conserved Myc (show MYC Antibodies) region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 (show HDAC1 Antibodies) is recruited to Myc (show MYC Antibodies)-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc (show MYC Antibodies).
this study highlights an essential role for Sin3B in IFN-c induced COL1A2 (show COL1A2 Antibodies) repression in smooth muscle cells.
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
the essential role of Sin3B as an important associate of p53 (show TP53 Antibodies) in mediating the cellular responses to stress and in the transcriptional repression of genes
identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1 (show HDAC1 Antibodies), Mrg15 (show MORF4L1 Antibodies), and the PHD (show PDC Antibodies) finger-containing Pf1 (show PHF12 Antibodies)
disruption of the function of a specific Sin3A (show SIN3A Antibodies)/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells
SMAR1 (show BANP Antibodies) regulates cyclin D1 (show CCND1 Antibodies) by modification of chromatin through the SIN3/histone deacetylase 1 (show HDAC1 Antibodies) complex
The interaction between SIN3B and ETO (show RUNX1T1 Antibodies) required an intact amino-terminus of ETO (show RUNX1T1 Antibodies) and the NHR2 domain.
Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 (show BMI1 Antibodies) depletion.
interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.
Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population
Results describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
RNF220 was identified as a novel ubiquitin ligase for Sin3B.
ESET (show SETDB1 Antibodies) histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1 (show HDAC1 Antibodies)/2 that participates in multiple pathways of transcriptional repression.
When tethered in cis (show CISH Antibodies) to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py) ori-dependent DNA replication in vivo.
Phe-7 is the critical determinant and provides the molecular specificity for the association between Sin3 and Mad in regulating cell growth and differentiation.
The Myt1 (show MYT1 Antibodies) family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B. Depending on the relative availability of Sin3B isoforms, the Myt1 (show MYT1 Antibodies) gene family may favor the silencing of genes during neural development.
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).
paired amphipathic helix protein Sin3b
, SIN3 homolog B, transcription regulator
, SIN3 homolog B, transcriptional regulator
, SIN3 transcription regulator homolog B
, histone deacetylase complex subunit Sin3b
, transcriptional corepressor Sin3b
, transcriptional regulator, SIN3B
, transcriptional regulator, SIN3 yeast homolog B