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SIVA1 encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. Additionally we are shipping SIVA1 Antibodies (41) and SIVA1 Kits (8) and many more products for this protein.
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Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
These findings collectively reveal a novel role for the p53 (show TP53 Proteins) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (show TP53 Proteins).
Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
electrical stimulation -inducible SIVA1 modulates p53 (show TP53 Proteins) activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53 (show TP53 Proteins)/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
SIVA1 interacts with RAD18 (show RAD18 Proteins) and serves as a molecular bridge between RAD18 (show RAD18 Proteins) and PCNA (show PCNA Proteins), thus targeting the E3 ligase activity of RAD18 (show RAD18 Proteins) onto PCNA (show PCNA Proteins).
Siva1 promotes the ubiquitination and degradation of ARF, which in turn affects the stability of p53 (show TP53 Proteins).
Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol.
negative regulator of IL-2 gene expression in Treg cells
Data show that low levels of Siva1 and Ser16-phosphorylated stathmin (show STMN1 Proteins) correlate with high metastatic states of breast cancer cells.
These findings suggest that the caspase (show CASP3 Proteins)-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.
Data indicate that p53 (show TP53 Proteins) target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
SIVA is a direct transcriptional target for the tumor suppressors p53 (show TP53 Proteins) and E2F1 (show E2F1 Proteins)
Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53 (show TP53 Proteins)-dependent apoptosis in cerebellar granule neurons.
lysophosphatidic acid 2 (show PTOV1 Proteins) receptor mediates down-regulation of Siva-1 to promote cell survival
Data show that SLIMMER (show FHL1 Proteins) delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
CD27-binding (Siva) protein
, apoptosis regulatory protein Siva
, CD27-binding protein
, Cd27 binding protein