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The protein encoded by SIX1 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. Additionally we are shipping SIX Homeobox 1 Antibodies (35) and SIX Homeobox 1 Proteins (6) and many more products for this protein.
Downregulation of Six1 effectively inhibited airway inflammation and reversed airway remodeling, which suggest that Six1 represents a promising therapeutic strategy for human allergic asthma.
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Six1 knockdown caused a fast-to-slow shift in myosin heavy chain isoform
Results suggest that the increase of SIX1 expression could promote tumorigenesis, progression and invasive growth of cervical cancer by promoting DNA replication.
Fast myosin heavy chain (show MYH8 ELISA Kits) (MYH (show MUTYH ELISA Kits)) genes and linc-MYH (show MUTYH ELISA Kits) share a common enhancer, located in the fast MYH (show MUTYH ELISA Kits) gene locus and regulated by Six1 homeoproteins
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Six1 is required for the proper chromatin structure at the Core Enhancer Region, as well as for MyoD (show MYOD1 ELISA Kits) binding at its own enhancer.
Results indicated that sine oculis homeobox (show PRRX1 ELISA Kits) 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1 (show ATP2A1 ELISA Kits), Srl (show SRL ELISA Kits), and Mylpf (show MYLPF ELISA Kits).
study replicated the association of POAG with two SNPs at the SIX1-SIX6 (show SIX6 ELISA Kits) locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 ELISA Kits) in patients aged above 40 years
miR (show MLXIP ELISA Kits)-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells.
Pro-survival effects by NF-kappaB (show NFKB1 ELISA Kits), Akt (show AKT1 ELISA Kits) and ERK(1 (show MAPK3 ELISA Kits)/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 (show TNFRSF10B ELISA Kits) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Upregulation of Six1 could downregulate miR (show MLXIP ELISA Kits)-204-5p expression.
Mutations of SIX1 gene underlie Wilms tumor recurrences.
Six1 signaling has a role in paclitaxel-dependent apoptosis in MCF-7 cell line
Six1 mutations/gene deletion are unlikely to be a major cause of nonsyndromic CAKUT.
Data show that the protein domain interfaces may represent therapeutic targets in homeo domain protein SIX1-positive Hodgkin lymphoma (HL) subsets.
Data show that both Ezrin (show EZR ELISA Kits) and SIX1 proteins are highly expressed in alpha fetoprotein (show AFP ELISA Kits)-negative hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) and significantly related with the TNM (show ODZ1 ELISA Kits) stage.
The HD domain is important for the nuclear localization of porcine Six1 protein.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
Eya1 (show EYA1 ELISA Kits) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1