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The protein encoded by SIX1 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. Additionally we are shipping SIX Homeobox 1 Antibodies (29) and many more products for this protein.
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Human SIX1 Protein expressed in Escherichia coli (E. coli) - ABIN1098684
Oliver, Wehr, Jenkins, Copeland, Cheyette, Hartenstein, Zipursky, Gruss: Homeobox genes and connective tissue patterning. in Development (Cambridge, England) 1995
Show all 2 references for ABIN1098684
Human SIX1 Protein expressed in Wheat germ - ABIN1320061
Yu, Davicioni, Triche, Merlino: The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. in Cancer research 2006
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Six1 knockdown caused a fast-to-slow shift in myosin heavy chain isoform
Results suggest that the increase of SIX1 expression could promote tumorigenesis, progression and invasive growth of cervical cancer by promoting DNA replication.
Fast myosin heavy chain (show MYH8 Proteins) (MYH (show MUTYH Proteins)) genes and linc-MYH (show MUTYH Proteins) share a common enhancer, located in the fast MYH (show MUTYH Proteins) gene locus and regulated by Six1 homeoproteins
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Six1 is required for the proper chromatin structure at the Core Enhancer Region, as well as for MyoD (show MYOD1 Proteins) binding at its own enhancer.
Results indicated that sine oculis homeobox (show PRRX1 Proteins) 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1 (show ATP2A1 Proteins), Srl (show SRL Proteins), and Mylpf (show MYLPF Proteins).
These findings uncover novel functions for Six1-Eya1 (show EYA1 Proteins)-SHH (show SHH Proteins) pathway during the saccular phase of lung morphogenesis.
the transcription factors Six1 and Six4 (show SIX4 Proteins) are required for male gonadal differentiation.
Data show that the protein domain interfaces may represent therapeutic targets in homeo domain protein SIX1-positive Hodgkin lymphoma (HL) subsets.
Data show that both Ezrin (show EZR Proteins) and SIX1 proteins are highly expressed in alpha fetoprotein (show AFP Proteins)-negative hepatocellular carcinoma (HCC (show FAM126A Proteins)) and significantly related with the TNM (show ODZ1 Proteins) stage.
Single nucleotide polymorphism in SIX1 gene is associated with primary open angle glaucoma.
High expression of SIX1 is an independent prognostic marker in colorectal cancer.
Three causative genes for BOR (show EYA1 Proteins) syndrome have been reported thus far: EYA1 (show EYA1 Proteins), SIX1, and SIX5, but the causative genes for approximately half of all BOR (show EYA1 Proteins) patients remain unknown.[review]
SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 (show EYA2 Proteins) interaction has been shown to be critical for metastasis in a breast cancer model.
Six1 plays an important role in the TIC (show ARNTL Proteins) population in luminal breast cancers and induces a TIC (show ARNTL Proteins) phenotype by enhancing both TGF-beta (show TGFB1 Proteins) and ERK (show EPHB2 Proteins) signaling.
SIX1 plays an important role in the progression ofhepatocellular carcinoma
in tumors with DGCR8 (show DGCR8 Proteins) E518K and DROSHA (show DROSHA Proteins) exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1/2 Q177R mutations
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 (show SIX2 Proteins) in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA (show DROSHA Proteins)/DGCR8 (show DGCR8 Proteins) microprocessor genes
The HD domain is important for the nuclear localization of porcine Six1 protein.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
Eya1 (show EYA1 Proteins) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1