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The protein encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. Additionally we are shipping SIX Homeobox 6 Antibodies (38) and SIX Homeobox 6 Kits (1) and many more products for this protein.
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SIX3 and SIX6 play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.
Six6-null mice display abnormal patterns of circadian behavior.
SoxB1 transcription factors are direct activators of Six6 expression in the ventral forebrain
Six6 plays an important role in the regulation of GnRH expression and hypothalamic control of fertility.
in association with Dach (show DACH1 Proteins) corepressors, regulates proliferation of retinal and pituitary precursor cells by directly repressing cyclin-dependent kinase (show CDK1 Proteins) inhibitors, including the p27Kip1 (show CDKN1B Proteins) promoter
Six 3 and Six 6 are differentially required during forebrain development; gene expression in brain
Results show that Lhx2 (show LHX2 Proteins) and Pax6 (show PAX6 Proteins) transcription factors operate in a concerted manner during retinal development to promote transcriptional activation of the Six6 homeobox (show PRRX1 Proteins)-gene in primitive and mature retinal progenitors.
Data show that both six6.L and six6.S expression was restricted to the retina and optic stalk of tailbud embryos.
2 evolutionary conserved regions 5' and a third 3' to the six6 coding region were identified. The conserved 3' region was necessary and sufficient for eye field and optic vesicle expression. Both conserved enhancer regions located 5' of the coding sequence were required for normal optic cup and mature retinal expression.
study replicated the association of POAG with two SNPs at the SIX1 (show SIX1 Proteins)-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 Proteins) in patients aged above 40 years
Six1 (show SIX1 Proteins) regulates p53 (show TP53 Proteins) via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26 (show RPL26 Proteins).
Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma.
SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression.
we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina.
Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma.
Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells.
No evidence was found that SIX6 mutations underlie human congenital structural eye malformations.
Six6 and Six2 (show SIX2 Proteins) differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase (show ACP1 Proteins) Eyes Absent in Six2 (show SIX2 Proteins)/6-DNA-binding ability.
BOR (show EYA1 Proteins) and OAVS features are associated with duplication of SIX1 (show SIX1 Proteins), SIX6 and OTX2 (show OTX2 Proteins) resulting from a complex chromosomal rearrangement.
a new helix in the C-terminal domain of the mutated bovine SIX6 protein was revealed, which possibly affects pituitary development and hormone secretion
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
homeobox protein SIX6
, optic homeobox 2
, sine oculis homeobox homolog 6
, sine oculis-related homeobox 6 homolog
, sine oculis-related homeobox 6a
, homeobox protein Optx2
, homeodomain protein OPTX2