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The protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). Additionally we are shipping SKI-Like Oncogene Antibodies (89) and SKI-Like Oncogene Kits (2) and many more products for this protein.
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Loss of SnoN is associated with partial embryonic lethality, mostly due to defects in angiogenesis in both the yolk sac (show ADCY10 Proteins) and embryo body
SnoN mediates a negative feedback mechanism evoked by TGF-beta to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes.
SnoN, a negative regulator of TGF-beta (show TGFB1 Proteins) signaling, coordinates TGF-beta (show TGFB1 Proteins) and prolactin (show PRL Proteins) signaling to control alveologenesis and lactogenesis.
mRNA for positive regulators of Fshb (show FSHB Proteins) expression, such as Fos and Jun (show JUN Proteins), were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the corepressors Skil, Crem (show CREM Proteins), and Tgif1 (show TGIF1 Proteins).
The endogenous SnoN plays a role in regulating ADAM12 (show ADAM12 Proteins) expression in response to TGFbeta1 (show TGFB1 Proteins).
The authors conclude that somatic and germ cells at all differentiation stages are actively transducing TGFbeta (show TGFB1 Proteins) superfamily signals but that responses to these ligands may be selectively modulated by SnoN2.
Sno is a significant negative regulator of antiproliferative TGF-beta (show TGFB1 Proteins) signaling in both T cells and other cell types in vivo
SnoN is directly regulated by sumoylation leading to the enhancement of the ability of SnoN to repress transcription in a promoter-specific manner
SnoN plays both pro-tumorigenic and antitumorigenic roles at different stages of mammalian malignant progression
Arkadia (show RNF111 Proteins) induces degradation of SnoN and c-Ski (show SKI Proteins) in addition to Smad7 (show SMAD7 Proteins).
RNAi-mediated downregulation of SnoN effectively inhibited proliferation and enhanced apoptosis of pancreatic cells.
SKIL knockdown led to growth arrest in PC-3 (show PCSK1 Proteins) and LNCaP cell line models of prostate cancer, and its overexpression led to increased invasiveness in RWPE-1 cells.
Whole exome sequencing of the blood of the patient and both parents revealed a de novo germline SKIL mutation in the child that was not present in either parent
Data indicate that tripartite motif containing 33 (show TRIM33 Proteins) protein TIF1gamma (show TRIM33 Proteins) promotes sumoylation of SKI-like proto-oncogene (show RAB1A Proteins) protein SnoN1 and regulates epithelial-mesenchymal transition (EMT (show ITK Proteins)).
The results indicate that protein ubiquitination promotes megakaryopoiesis via degrading SnoN, an inhibitor of CD61 (show ITGB3 Proteins) expression, strengths the roles of ubiquitination in cellular differentiation.
SnoNspecific siRNA is capable of effectively inhibiting the expression of SnoN in human HepG2 cells, and the downregulation of SnoN expression induces growth inhibition and apoptosis
these studies identify TLOC1 (show TLOC1 Proteins) and SKIL as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain.
High SnoN expression is associated with metastasis in breast cancer.
Phospholipid Scramblase 1 (show PLSCR1 Proteins), an interferon (show IFNA Proteins)-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells.
These data strongly suggest that SnoN can function as a tumor suppressor at early stages of tumorigenesis in human cancer tissues.
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
, Ski-like protein
, ski-like protein-like
, ski-like protein
, ski-related oncogene
, ski/sno related
, ski-related oncogene snoN
, v-ski sarcoma viral oncogene homolog