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The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. Additionally we are shipping SLAMF6 Proteins (20) and SLAMF6 Kits (2) and many more products for this protein.
Showing 10 out of 72 products:
Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2665674
Falco, Marcenaro, Romeo, Bellora, Marras, Vély, Ferracci, Moretta, Moretta, Bottino: Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells. in European journal of immunology 2004
Show all 8 references for ABIN2665674
Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2663403
Flaig, Stark, Watzl: Cutting edge: NTB-A activates NK cells via homophilic interaction. in Journal of immunology (Baltimore, Md. : 1950) 2004
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Human Monoclonal SLAMF6 Primary Antibody for ELISA, WB - ABIN2664606
Kumar, Li, Yan, Bhaskarabhatla, Mobley, Nguyen, Mooney, Schatzle, Wakeland, Mohan: Regulation of B cell tolerance by the lupus susceptibility gene Ly108. in Science (New York, N.Y.) 2006
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Mouse (Murine) Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2663834
Peck, Ruley: Ly108: a new member of the mouse CD2 family of cell surface proteins. in Immunogenetics 2000
Show all 5 references for ABIN2663834
Mouse (Murine) Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2662362
Zhong, Veillette: Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity. in The Journal of biological chemistry 2008
Show all 4 references for ABIN2662362
Human Polyclonal SLAMF6 Primary Antibody for EIA, WB - ABIN954817
Hanna, Kruskal, Ezekowitz, Bloom, Collier: Role of macrophage oxidative burst in the action of anthrax lethal toxin. in Molecular medicine (Cambridge, Mass.) 1996
Show all 2 references for ABIN954817
Human Polyclonal SLAMF6 Primary Antibody for WB - ABIN530287
Proust, Bertoglio, Gesbert: The adaptor protein SAP directly associates with CD3? chain and regulates T cell receptor signaling. in PLoS ONE 2012
Human Polyclonal SLAMF6 Primary Antibody for WB - ABIN2784101
Claus, Meinke, Bhat, Watzl: Regulation of NK cell activity by 2B4, NTB-A and CRACC. in Frontiers in bioscience : a journal and virtual library 2007
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
our data reveal how SAP (show APCS Antibodies) nucleates a previously unknown signaling complex involving NTB-A and LCK (show LCK Antibodies) to potentiate restimulation-induced cell death of activated human T cells.
Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Data indicate that the dominance of the SLAMF3 (show LY9 Antibodies)/SLAMF6 pathway in inducing IL-17A (show IL17A Antibodies) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (show IL17A Antibodies) promoter.
SLAMF3 (show LY9 Antibodies) and SLAMF6 T cell surface expression and IL-17 (show IL17A Antibodies) levels significantly correlate with disease activity in systemic lupus erythematosus patients
Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (show TH1L Antibodies) and IL-2 (show IL2 Antibodies) cytokine production
Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.
regulation of interferon-gamma (show IFNG Antibodies) secretion, and not interleukin-4 (show IL4 Antibodies) in vitro, as well as inhibition of Th1 (show TH1L Antibodies) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity
study establishes a central role for germinal center B cell-specific CD84 (show CD84 Antibodies) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (show CD247 Antibodies) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (show CD247 Antibodies) dephosphorylation.
Ly108 expression distinguishes subsets of invariant NKT (show CTSL1 Antibodies) cells that help autoantibody production and secrete IL-21 (show IL21 Antibodies) from those that secrete IL-17 (show IL17A Antibodies) in lupus prone NZB/W mice.
Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (show SPP1 Antibodies)+ T follicular helper (TFH) cells.
Ly108 plays a role in the induction of PLZF (show ZBTB16 Antibodies) in developing thymocytes.
In the absence of SAP (show APCS Antibodies), signaling through the SLAM (show SLAMF1 Antibodies) family members Ly108 and 2B4 (show CD244 Antibodies) resulted in increased recruitment of the SHP-1 (show PTPN6 Antibodies) phosphatase, associated with altered SHP-1 (show PTPN6 Antibodies) localization and decreased activation of Src (show SRC Antibodies) kinases at the synapse.
Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.
3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.
an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
SLAM family member 6
, activating NK receptor
, NTBA receptor
, natural killer-, T- and B-cell antigen
, lymphocyte antigen 108