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anti-SLAM Family Member 6 (SLAMF6) Antibodies

The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. Additionally we are shipping SLAMF6 Proteins (18) and SLAMF6 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLAMF6 114836 Q96DU3
SLAMF6 30925 Q9ET39
SLAMF6 498287  
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Top anti-SLAMF6 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SLAMF6 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of  CD352 / SLAMF6 Antibody (C-term) Cat.-No AP53926PU-N in T47D cell line lysates (35ug/lane). This demonstrates the SLAMF6 antibody detected the SLAMF6 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Mouse Pacific Blue FACS 100 μg Log in to see 10 to 12 Days
$298.95
Details
Mouse Mouse PE FACS 100 μg Log in to see 10 to 12 Days
$320.68
Details
Human Mouse Un-conjugated FACS 100 μg Log in to see 8 to 10 Days
$346.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of SLAMF6 expression in transfected 293T cell line by SLAMF6 MaxPab polyclonal antibody.Lane 1: SLAMF6 transfected lysate(29.81 KDa).Lane 2: Non-transfected lysate. SLAMF6 MaxPab polyclonal antibody. Western Blot analysis of SLAMF6 expression in human spleen. 50 μL Log in to see 9 Days
$430.00
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$260.89
Details
Human Rabbit Un-conjugated WB SLAMF6 Antibody (C-term)  western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SLAMF6 antibody detected the SLAMF6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS 500 μg Log in to see 10 to 12 Days
$429.39
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 10 to 12 Days
$114.15
Details

SLAMF6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus)


Top referenced anti-SLAMF6 Antibodies

  1. Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2663403 : Falco, Marcenaro, Romeo, Bellora, Marras, Vély, Ferracci, Moretta, Moretta, Bottino: Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells. in European journal of immunology 2004 (PubMed)
    Show all 8 references for ABIN2663403

  2. Human Monoclonal SLAMF6 Primary Antibody for ELISA, WB - ABIN2664606 : Flaig, Stark, Watzl: Cutting edge: NTB-A activates NK cells via homophilic interaction. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 8 references for ABIN2664606

  3. Human Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2665674 : Kumar, Li, Yan, Bhaskarabhatla, Mobley, Nguyen, Mooney, Schatzle, Wakeland, Mohan: Regulation of B cell tolerance by the lupus susceptibility gene Ly108. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 8 references for ABIN2665674

  4. Mouse (Murine) Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2663834 : Peck, Ruley: Ly108: a new member of the mouse CD2 family of cell surface proteins. in Immunogenetics 2000 (PubMed)
    Show all 5 references for ABIN2663834

  5. Mouse (Murine) Monoclonal SLAMF6 Primary Antibody for FACS - ABIN2662362 : Zhong, Veillette: Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity. in The Journal of biological chemistry 2008 (PubMed)
    Show all 4 references for ABIN2662362

  6. Human Polyclonal SLAMF6 Primary Antibody for EIA, WB - ABIN954817 : Hanna, Kruskal, Ezekowitz, Bloom, Collier: Role of macrophage oxidative burst in the action of anthrax lethal toxin. in Molecular medicine (Cambridge, Mass.) 1996 (PubMed)
    Show all 2 references for ABIN954817

  7. Human Polyclonal SLAMF6 Primary Antibody for WB - ABIN530287 : Proust, Bertoglio, Gesbert: The adaptor protein SAP directly associates with CD3? chain and regulates T cell receptor signaling. in PLoS ONE 2012 (PubMed)

  8. Human Polyclonal SLAMF6 Primary Antibody for WB - ABIN2784102 : Claus, Meinke, Bhat, Watzl: Regulation of NK cell activity by 2B4, NTB-A and CRACC. in Frontiers in bioscience : a journal and virtual library 2007 (PubMed)

More Antibodies against SLAMF6 Interaction Partners

Human SLAM Family Member 6 (SLAMF6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. our data reveal how SAP (show APCS Antibodies) nucleates a previously unknown signaling complex involving NTB-A and LCK (show LCK Antibodies) to potentiate restimulation-induced cell death of activated human T cells.

  3. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.

  4. Data indicate that the dominance of the SLAMF3 (show LY9 Antibodies)/SLAMF6 pathway in inducing IL-17A (show IL17A Antibodies) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (show IL17A Antibodies) promoter.

  5. SLAMF3 (show LY9 Antibodies) and SLAMF6 T cell surface expression and IL-17 (show IL17A Antibodies) levels significantly correlate with disease activity in systemic lupus erythematosus patients

  6. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (show TH1L Antibodies) and IL-2 (show IL2 Antibodies) cytokine production

  7. Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.

  8. regulation of interferon-gamma (show IFNG Antibodies) secretion, and not interleukin-4 (show IL4 Antibodies) in vitro, as well as inhibition of Th1 (show TH1L Antibodies) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response

  9. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.

  10. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity

Mouse (Murine) SLAM Family Member 6 (SLAMF6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. study establishes a central role for germinal center B cell-specific CD84 (show CD84 Antibodies) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity

  3. When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (show CD247 Antibodies) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (show CD247 Antibodies) dephosphorylation.

  4. Ly108 expression distinguishes subsets of invariant NKT (show CTSL1 Antibodies) cells that help autoantibody production and secrete IL-21 (show IL21 Antibodies) from those that secrete IL-17 (show IL17A Antibodies) in lupus prone NZB/W mice.

  5. Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (show SPP1 Antibodies)+ T follicular helper (TFH) cells.

  6. Ly108 plays a role in the induction of PLZF (show ZBTB16 Antibodies) in developing thymocytes.

  7. In the absence of SAP (show APCS Antibodies), signaling through the SLAM (show SLAMF1 Antibodies) family members Ly108 and 2B4 (show CD244 Antibodies) resulted in increased recruitment of the SHP-1 (show PTPN6 Antibodies) phosphatase, associated with altered SHP-1 (show PTPN6 Antibodies) localization and decreased activation of Src (show SRC Antibodies) kinases at the synapse.

  8. Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.

  9. 3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.

  10. an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

SLAMF6 Antigen Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SLAMF6

  • SLAM family member 6 (SLAMF6) antibody
  • SLAM family member 6 (Slamf6) antibody
  • CD352 antibody
  • KAL1 antibody
  • KAL1b antibody
  • KALI antibody
  • KALIb antibody
  • Ly108 antibody
  • NTB-A antibody
  • NTBA antibody
  • RGD1561848 antibody
  • SF2000 antibody
  • SLAMF6 antibody

Protein level used designations for SLAMF6

SLAM family member 6 , activating NK receptor , NK-T-B-antigen , NTBA receptor , natural killer-, T- and B-cell antigen , lymphocyte antigen 108

GENE ID SPECIES
508183 Bos taurus
719728 Macaca mulatta
746886 Pan troglodytes
100156912 Sus scrofa
114836 Homo sapiens
30925 Mus musculus
498287 Rattus norvegicus
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