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The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. Additionally we are shipping SLAMF6 Antibodies (62) and SLAMF6 Kits (1) and many more products for this protein.
Showing 10 out of 18 products:
Human SLAMF6 Protein expressed in Human Cells - ABIN2004912
Valdez, Wang, Seshasayee, van Lookeren Campagne, Gurney, Lee, Grewal: NTB-A, a new activating receptor in T cells that regulates autoimmune disease. in The Journal of biological chemistry 2004
Show all 2 references for ABIN2004912
Human SLAMF6 Protein expressed in Human Cells - ABIN2004910
Claus, Meinke, Bhat, Watzl: Regulation of NK cell activity by 2B4, NTB-A and CRACC. in Frontiers in bioscience : a journal and virtual library 2007
Show all 2 references for ABIN2004910
Human SLAMF6 Protein expressed in Escherichia coli (E. coli) - ABIN1098703
Aversa, Carballido, Punnonen, Chang, Hauser, Cocks, De Vries: SLAM and its role in T cell activation and Th cell responses. in Immunology and cell biology 1997
Show all 2 references for ABIN1098703
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
our data reveal how SAP (show APCS Proteins) nucleates a previously unknown signaling complex involving NTB-A and LCK (show LCK Proteins) to potentiate restimulation-induced cell death of activated human T cells.
Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.
Data indicate that the dominance of the SLAMF3 (show LY9 Proteins)/SLAMF6 pathway in inducing IL-17A (show IL17A Proteins) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (show IL17A Proteins) promoter.
SLAMF3 (show LY9 Proteins) and SLAMF6 T cell surface expression and IL-17 (show IL17A Proteins) levels significantly correlate with disease activity in systemic lupus erythematosus patients
Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (show TH1L Proteins) and IL-2 (show IL2 Proteins) cytokine production
Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.
regulation of interferon-gamma (show IFNG Proteins) secretion, and not interleukin-4 (show IL4 Proteins) in vitro, as well as inhibition of Th1 (show TH1L Proteins) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity
study establishes a central role for germinal center B cell-specific CD84 (show CD84 Proteins) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (show CD247 Proteins) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (show CD247 Proteins) dephosphorylation.
Ly108 expression distinguishes subsets of invariant NKT (show CTSL1 Proteins) cells that help autoantibody production and secrete IL-21 (show IL21 Proteins) from those that secrete IL-17 (show IL17A Proteins) in lupus prone NZB/W mice.
Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (show SPP1 Proteins)+ T follicular helper (TFH) cells.
Ly108 plays a role in the induction of PLZF (show ZBTB16 Proteins) in developing thymocytes.
In the absence of SAP (show APCS Proteins), signaling through the SLAM (show SLAMF1 Proteins) family members Ly108 and 2B4 (show CD244 Proteins) resulted in increased recruitment of the SHP-1 (show PTPN6 Proteins) phosphatase, associated with altered SHP-1 (show PTPN6 Proteins) localization and decreased activation of Src (show SRC Proteins) kinases at the synapse.
Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.
3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.
an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
SLAM family member 6
, activating NK receptor
, NTBA receptor
, natural killer-, T- and B-cell antigen
, lymphocyte antigen 108