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SLAM Family Member 6 Proteins (SLAMF6)

The protein encoded by SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. Additionally we are shipping SLAMF6 Antibodies (61) and SLAMF6 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLAMF6 114836 Q96DU3
SLAMF6 30925 Q9ET39
Rat SLAMF6 SLAMF6 498287  
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Top SLAMF6 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$269.50
Details

SLAMF6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) , , ,
,

Top referenced SLAMF6 Proteins

  1. Human SLAMF6 Protein expressed in Human Cells - ABIN2004912 : Valdez, Wang, Seshasayee, van Lookeren Campagne, Gurney, Lee, Grewal: NTB-A, a new activating receptor in T cells that regulates autoimmune disease. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN2004912

  2. Human SLAMF6 Protein expressed in Human Cells - ABIN2004910 : Claus, Meinke, Bhat, Watzl: Regulation of NK cell activity by 2B4, NTB-A and CRACC. in Frontiers in bioscience : a journal and virtual library 2007 (PubMed)
    Show all 2 references for ABIN2004910

  3. Human SLAMF6 Protein expressed in Escherichia coli (E. coli) - ABIN1098703 : Aversa, Carballido, Punnonen, Chang, Hauser, Cocks, De Vries: SLAM and its role in T cell activation and Th cell responses. in Immunology and cell biology 1997 (PubMed)
    Show all 2 references for ABIN1098703

More Proteins for SLAM Family Member 6 (SLAMF6) Interaction Partners

Human SLAM Family Member 6 (SLAMF6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. our data reveal how SAP (show APCS Proteins) nucleates a previously unknown signaling complex involving NTB-A and LCK (show LCK Proteins) to potentiate restimulation-induced cell death of activated human T cells.

  3. Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules.

  4. Data indicate that the dominance of the SLAMF3 (show LY9 Proteins)/SLAMF6 pathway in inducing IL-17A (show IL17A Proteins) production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A (show IL17A Proteins) promoter.

  5. SLAMF3 (show LY9 Proteins) and SLAMF6 T cell surface expression and IL-17 (show IL17A Proteins) levels significantly correlate with disease activity in systemic lupus erythematosus patients

  6. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 (show TH1L Proteins) and IL-2 (show IL2 Proteins) cytokine production

  7. Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells.

  8. regulation of interferon-gamma (show IFNG Proteins) secretion, and not interleukin-4 (show IL4 Proteins) in vitro, as well as inhibition of Th1 (show TH1L Proteins) cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response

  9. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.

  10. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity

Mouse (Murine) SLAM Family Member 6 (SLAMF6) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. study establishes a central role for germinal center B cell-specific CD84 (show CD84 Proteins) and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity

  3. When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta (show CD247 Proteins) interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta (show CD247 Proteins) dephosphorylation.

  4. Ly108 expression distinguishes subsets of invariant NKT (show CTSL1 Proteins) cells that help autoantibody production and secrete IL-21 (show IL21 Proteins) from those that secrete IL-17 (show IL17A Proteins) in lupus prone NZB/W mice.

  5. Data indicate that Slamf6-H1 suppresses the spontaneous expansion of a unique osteopontin OPN (show SPP1 Proteins)+ T follicular helper (TFH) cells.

  6. Ly108 plays a role in the induction of PLZF (show ZBTB16 Proteins) in developing thymocytes.

  7. In the absence of SAP (show APCS Proteins), signaling through the SLAM (show SLAMF1 Proteins) family members Ly108 and 2B4 (show CD244 Proteins) resulted in increased recruitment of the SHP-1 (show PTPN6 Proteins) phosphatase, associated with altered SHP-1 (show PTPN6 Proteins) localization and decreased activation of Src (show SRC Proteins) kinases at the synapse.

  8. Ly 108 deletion in T4 cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers and restoring NKT-cell differentiation. This required immunotyrosine switch motifs (ITSMs) & SHP-1 recruitment.

  9. 3 isoforms of Ly108 mRNA & protein are differentially expressed in the thymi of C57BL/6 & 129S6 mice expressing the lupus-resistant & lupus-prone haplotypes of Ly108, respectively. Ly108-H1 is a decoy isoform.

  10. an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

SLAMF6 Protein Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SLAM Family Member 6 Proteins (SLAMF6)

  • SLAM family member 6 (SLAMF6)
  • SLAM family member 6 (Slamf6)
  • CD352 protein
  • KAL1 protein
  • KAL1b protein
  • KALI protein
  • KALIb protein
  • Ly108 protein
  • NTB-A protein
  • NTBA protein
  • RGD1561848 protein
  • SF2000 protein
  • SLAMF6 protein

Protein level used designations for SLAM Family Member 6 Proteins (SLAMF6)

SLAM family member 6 , activating NK receptor , NK-T-B-antigen , NTBA receptor , natural killer-, T- and B-cell antigen , lymphocyte antigen 108

GENE ID SPECIES
508183 Bos taurus
719728 Macaca mulatta
746886 Pan troglodytes
100156912 Sus scrofa
114836 Homo sapiens
30925 Mus musculus
498287 Rattus norvegicus
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