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Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Additionally we are shipping SLITRK5 Antibodies (35) and SLITRK5 Proteins (6) and many more products for this protein.
This study did not find any evidence supporting the association of Tourette syndrome and SLITRK5.
Slitrk5 modulates brain-derived neurotrophic factor (BDNF (show BDNF ELISA Kits))-dependent biological responses through direct interaction with TrkB (show NTRK2 ELISA Kits) receptors. Under basal conditions, Slitrk5 interacts with a transsynaptic binding partner, protein tyrosine phosphatase delta (show PTPRD ELISA Kits).
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive behaviors in mice.
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1\; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003
SLIT and NTRK-like family, member 5
, SLIT and NTRK-like protein 5-like
, SLIT and NTRK-like protein 5
, leucine rich repeat containing 11
, leucine-rich repeat-containing protein 11
, slit and trk like gene 5