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Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Additionally we are shipping SLITRK5 Antibodies (39) and SLITRK5 Kits (1) and many more products for this protein.
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Mutation in SLITRK5 gene is Associated with Obsessive Compulsive Disorder
This study did not find any evidence supporting the association of Tourette syndrome and SLITRK5.
Slitrk5 modulates brain-derived neurotrophic factor (BDNF (show BDNF Proteins))-dependent biological responses through direct interaction with TrkB (show NTRK2 Proteins) receptors. Under basal conditions, Slitrk5 interacts with a transsynaptic binding partner, protein tyrosine phosphatase delta (show PTPRD Proteins).
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive behaviors in mice.
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1\; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003
SLIT and NTRK-like family, member 5
, SLIT and NTRK-like protein 5-like
, SLIT and NTRK-like protein 5
, leucine rich repeat containing 11
, leucine-rich repeat-containing protein 11
, slit and trk like gene 5