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GTPase-activating protein for RhoA and Cdc42 small GTPases. Additionally we are shipping SRGAP1 Antibodies (52) and many more products for this protein.
Showing 4 out of 4 products:
we identified a consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 x 10(-7))
Mutations of the SLIT2 (show SLIT3 Proteins)-ROBO2 (show ROBO2 Proteins) pathway genes SLIT2 (show SLIT3 Proteins) and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
The elevated miR (show MLXIP Proteins)-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype
The interaction of betaPix (show ARHGEF7 Proteins) with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 (show CDC42 Proteins) and RhoA (show RHOA Proteins) during 3D collagen migration.
Data indicate that srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a Rac1-dependent manner.
genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma.
This study proposed that the expression of SRGAP1 in the anterior neocortex may mark the early location of the human motor cortex, including its corticospinal projection neurons, allowing further study of their early differentiation.
FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.
Mutations of the SLIT2 (show SLIT2 Proteins)-ROBO2 (show ROBO2 Proteins) pathway genes SLIT2 (show SLIT2 Proteins) and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
srGAP1 and srGAP3 (show SRGAP3 Proteins) are largely expressed in subpopulations of dorsal root ganglion neurons following sciatic nerve lesion.
Data show that srGAP3 (show SRGAP3 Proteins) is expressed in ventricular zones of neurogenesis in many different tissues of the central nervous system.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
SLIT-ROBO Rho GTPase-activating protein 1
, SLIT-ROBO Rho GTPase activating protein 1
, SLIT-ROBO Rho GTPase-activating protein 1-like
, rho GTPase-activating protein 13
, Rho GTPase activating protein 13
, Rho GTPase activating protein