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SLIT-ROBO rho GTPase Activating Protein 1 Proteins (SRGAP1)

GTPase-activating protein for RhoA and Cdc42 small GTPases. Additionally we are shipping SRGAP1 Antibodies (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRGAP1 57522 Q7Z6B7
SRGAP1 117600 Q91Z69
Rat SRGAP1 SRGAP1 314903  
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Top SRGAP1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SRGAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1) Interaction Partners

Human SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1) interaction partners

  1. we identified a consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 x 10(-7))

  2. Mutations of the SLIT2 (show SLIT3 Proteins)-ROBO2 (show ROBO2 Proteins) pathway genes SLIT2 (show SLIT3 Proteins) and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract

  3. The elevated miR (show MLXIP Proteins)-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype

  4. The interaction of betaPix (show ARHGEF7 Proteins) with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 (show CDC42 Proteins) and RhoA (show RHOA Proteins) during 3D collagen migration.

  5. Data indicate that srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a Rac1-dependent manner.

  6. genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma.

  7. This study proposed that the expression of SRGAP1 in the anterior neocortex may mark the early location of the human motor cortex, including its corticospinal projection neurons, allowing further study of their early differentiation.

  8. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1) interaction partners

  1. Mutations of the SLIT2 (show SLIT2 Proteins)-ROBO2 (show ROBO2 Proteins) pathway genes SLIT2 (show SLIT2 Proteins) and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract

  2. srGAP1 and srGAP3 (show SRGAP3 Proteins) are largely expressed in subpopulations of dorsal root ganglion neurons following sciatic nerve lesion.

  3. Data show that srGAP3 (show SRGAP3 Proteins) is expressed in ventricular zones of neurogenesis in many different tissues of the central nervous system.

SRGAP1 Protein Profile

Protein Summary

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Gene names and symbols associated with SRGAP1

  • SLIT-ROBO Rho GTPase activating protein 1 (SRGAP1)
  • SLIT-ROBO Rho GTPase activating protein 1 (srgap1)
  • SLIT-ROBO Rho GTPase activating protein 1 (Srgap1)
  • 4930572H05Rik protein
  • Arhgap13 protein
  • RGD1566260 protein

Protein level used designations for SRGAP1

SLIT-ROBO Rho GTPase-activating protein 1 , SLIT-ROBO Rho GTPase activating protein 1 , SLIT-ROBO Rho GTPase-activating protein 1-like , rho GTPase-activating protein 13 , Rho GTPase activating protein 13 , Rho GTPase activating protein

GENE ID SPECIES
100051440 Equus caballus
452043 Pan troglodytes
100398023 Callithrix jacchus
100483353 Ailuropoda melanoleuca
100485190 Xenopus (Silurana) tropicalis
100584408 Nomascus leucogenys
57522 Homo sapiens
117600 Mus musculus
417821 Gallus gallus
481144 Canis lupus familiaris
100623414 Sus scrofa
539452 Bos taurus
314903 Rattus norvegicus
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