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This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Additionally we are shipping SRGAP2 Antibodies (17) and SRGAP2 Proteins (3) and many more products for this protein.
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This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.
interlocus gene conversions in SRGAP2
SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (show MBL2 ELISA Kits) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.
Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.
FNBP2 gene was linked to IKBKE (show IKBKE ELISA Kits) and NORE1 (show RASSF5 ELISA Kits) genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.
The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (show ARHGEF16 ELISA Kits) cells.
Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
SLIT-ROBO Rho GTPase-activating protein 2
, formin binding protein 2
, formin-binding protein 2
, rho GTPase-activating protein 34
, formin-binding protein 27