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anti-SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Antibodies

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. Additionally we are shipping SRGAP3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRGAP3 14270 Q91Z67
SRGAP3 9901 O43295
SRGAP3 500287  
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Top anti-SRGAP3 Antibodies at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry of Human esophagus cancer using SRGAP3 Polyclonal Antibody at dilution of 1:30 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 11 to 16 Days
$675.71
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$273.90
Details
Human Rabbit Un-conjugated IHC, WB   200 μL Log in to see 9 to 19 Days
$653.03
Details
Human Rabbit Un-conjugated   50 μL Log in to see 9 to 19 Days
$417.00
Details

SRGAP3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) ,


Human ,


Rat (Rattus) ,


More Antibodies against SRGAP3 Interaction Partners

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) interaction partners

  1. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.

  2. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.

  3. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (show ARHGEF16 Antibodies) cells.

  4. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus

  5. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.

  6. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.

  7. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.

  8. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.

  9. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.

  10. Results from these studies confirm that loss of WRP is linked to impaired learning and memory.

Human SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) interaction partners

  1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.

  2. Nuclear-localized srGAP3 interacts with Brg1 (show SMARCA4 Antibodies). This interaction is mediated by the C-terminal of srGAP3 and the ATPase (show DNAH8 Antibodies) motif of Brg1 (show SMARCA4 Antibodies).

  3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation.

  4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1

  5. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes.

  6. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

  7. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions.

  8. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.

SRGAP3 Antigen Profile

Protein Summary

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Gene names and symbols associated with SRGAP3

  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2) antibody
  • SLIT-ROBO Rho GTPase activating protein 3 (SRGAP3) antibody
  • SLIT-ROBO Rho GTPase activating protein 3 (Srgap3) antibody
  • 9930124L22Rik antibody
  • AI448945 antibody
  • AI452337 antibody
  • Arhgap14 antibody
  • D130026O08Rik antibody
  • FBP2 antibody
  • Fnbp2 antibody
  • Gbi antibody
  • MEGAP antibody
  • mKIAA0411 antibody
  • RGD1563152 antibody
  • SRGAP2 antibody
  • srGAP3 antibody
  • WRP antibody

Protein level used designations for SRGAP3

FBP-27 , SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , formin-binding protein 27 , SLIT-ROBO Rho GTPase activating protein 2 , SLIT-ROBO Rho GTPase-activating protein 3 , WAVE-associated Rac GTPase activating protein , mental disorder-associated GAP , rho GTPase-activating protein 14 , WAVE-associated Rac GTPase-activating protein , brain stress early protein Gbi , rho GTPase activating protein 14 , srGAP2

GENE ID SPECIES
14270 Mus musculus
9901 Homo sapiens
610229 Canis lupus familiaris
500287 Rattus norvegicus
259302 Mus musculus
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