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SLIT-ROBO rho GTPase Activating Protein 3 Proteins (SRGAP3)

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. Additionally we are shipping SRGAP3 Antibodies (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRGAP3 14270 Q91Z67
SRGAP3 9901 O43295
Rat SRGAP3 SRGAP3 500287  
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Top SRGAP3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SRGAP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaction Partners

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) interaction partners

  1. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.

  2. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.

  3. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (show ARHGEF16 Proteins) cells.

  4. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus

  5. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.

  6. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.

  7. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.

  8. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.

  9. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.

  10. Results from these studies confirm that loss of WRP is linked to impaired learning and memory.

Human SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) interaction partners

  1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.

  2. Nuclear-localized srGAP3 interacts with Brg1 (show SMARCA4 Proteins). This interaction is mediated by the C-terminal of srGAP3 and the ATPase motif of Brg1 (show SMARCA4 Proteins).

  3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation.

  4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1

  5. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes.

  6. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

  7. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions.

  8. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.

SRGAP3 Protein Profile

Protein Summary

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Gene names and symbols associated with SRGAP3

  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2)
  • SLIT-ROBO Rho GTPase activating protein 3 (SRGAP3)
  • SLIT-ROBO Rho GTPase activating protein 3 (Srgap3)
  • 9930124L22Rik protein
  • AI448945 protein
  • AI452337 protein
  • Arhgap14 protein
  • D130026O08Rik protein
  • FBP2 protein
  • Fnbp2 protein
  • Gbi protein
  • MEGAP protein
  • mKIAA0411 protein
  • RGD1563152 protein
  • SRGAP2 protein
  • srGAP3 protein
  • WRP protein

Protein level used designations for SRGAP3

FBP-27 , SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , formin-binding protein 27 , SLIT-ROBO Rho GTPase activating protein 2 , SLIT-ROBO Rho GTPase-activating protein 3 , WAVE-associated Rac GTPase activating protein , mental disorder-associated GAP , rho GTPase-activating protein 14 , WAVE-associated Rac GTPase-activating protein , brain stress early protein Gbi , rho GTPase activating protein 14 , srGAP2

GENE ID SPECIES
14270 Mus musculus
9901 Homo sapiens
610229 Canis lupus familiaris
500287 Rattus norvegicus
259302 Mus musculus
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