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SMAD, Mothers Against DPP Homolog 6 Proteins (SMAD6)

The protein encoded by SMAD6 belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. Additionally we are shipping SMAD6 Antibodies (144) and SMAD6 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMAD6 4091 O43541
SMAD6 17130 O35182
SMAD6 367100  
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Top SMAD6 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$362.88
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,202.83
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$838.20
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

SMAD6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for SMAD, Mothers Against DPP Homolog 6 (SMAD6) Interaction Partners

Human SMAD, Mothers Against DPP Homolog 6 (SMAD6) interaction partners

  1. Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer

  2. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (show UBE2O Proteins) and SMAD6 cooperated in the regulation of BMP7 (show BMP7 Proteins)-induced adipogenesis

  3. Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.

  4. Loss of SMAD6 is associated with lung adenocarcinoma.

  5. Congenital cardiovascular malformation is related to genetic variation in SMAD6

  6. Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.

  7. results suggest that MyD88 (show MYD88 Proteins) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (show TGFB1 Proteins)-mediated negative regulation of MyD88 (show MYD88 Proteins)-dependent pro-inflammatory signalling

  8. Data show that Runx1 (show RUNX1 Proteins), in conjunction with Fli1 (show FLI1 Proteins), Gata2 (show GATA2 Proteins), and Scl (show KRT7 Proteins), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.

  9. Smad6 and Smad7, inhibitors of BMP signaling, were up-regulated in HFE-mutant hereditary hemochromatosis compared to controls, disruptin bone morphogenic protein signaling.

  10. Smad6 together with Smad2 (show SMAD2 Proteins) may be prognostic factors, independent of nodal status in oral SCC (show CYP11A1 Proteins) after curative resection

Mouse (Murine) SMAD, Mothers Against DPP Homolog 6 (SMAD6) interaction partners

  1. A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (show NKX2-5 Proteins)).

  2. These results indicate that PRIP (show NCOA6 Proteins) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (show SMAD1 Proteins) phosphorylation, through the methylation of inhibitory Smad6

  3. These findings suggest that TNF-alpha (show TNF Proteins) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (show BMP2 Proteins) signaling inhibitor, Smad6.

  4. The Smad6 is a novel target of Arkadia (show RNF111 Proteins), and that Arkadia (show RNF111 Proteins) positively regulates BMP signalling via degradation of Smad6, Smad7 (show SMAD7 Proteins) and c-Ski (show SKI Proteins)/SnoN (show SKIL Proteins).

  5. Smad6 inhibits non-canonical TGF-beta1 (show TGFB1 Proteins) signaling by recruiting the deubiquitinase A20 (show TNFAIP3 Proteins) to TRAF6 (show TRAF6 Proteins).

  6. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (show UBE2O Proteins) and SMAD6 cooperated in the regulation of BMP7 (show BMP7 Proteins)-induced adipogenesis

  7. Hepcidin (show HAMP Proteins), Smad6 and Smad7 (show SMAD7 Proteins) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (show SMAD1 Proteins) signaling pathway.

  8. Sema7A (show SEMA7A Proteins) positively regulates the production of transforming growth factor (TGF)-beta1 (show TGFB1 Proteins) and Smad6 to facilitate West Nile virus pathogenesis in mice.

  9. Results indicate that peptidyl-prolyl isomerase Pin1 (show PIN1 Proteins) Associates with Smad3 (show SMAD3 Proteins) and Smad6.

  10. Data show that Runx1 (show RUNX1 Proteins), in conjunction with Fli1 (show FLI1 Proteins), Gata2 (show GATA2 Proteins), and Scl (show TAL1 Proteins), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.

SMAD6 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMAD6

  • SMAD family member 6 (smad6)
  • SMAD family member 6 (SMAD6)
  • SMAD family member 6 (Smad6)
  • SMAD family member 6a (smad6a)
  • AOVD2 protein
  • b2b390Clo protein
  • HsT17432 protein
  • Madh6 protein
  • MADH7 protein
  • smad6 protein
  • Smad6-like protein
  • wu:fb22g05 protein
  • Xsmad6 protein

Protein level used designations for SMAD6

SMAD, mothers against DPP homolog 6 , MAD homolog 6 , Mothers against decapentaplegic, drosophila, homolog of, 6 , SMAD 6 , hSMAD6 , mothers against DPP homolog 6 , mothers against decapentaplegic homolog 6 , Smad 6 , mad homolog 7 , MAD, mothers against decapentaplegic homolog 6

GENE ID SPECIES
100038072 Xenopus (Silurana) tropicalis
4091 Homo sapiens
17130 Mus musculus
367100 Rattus norvegicus
374096 Gallus gallus
487612 Canis lupus familiaris
511279 Bos taurus
116992 Danio rerio
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