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SMURF1 encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. Additionally we are shipping SMURF1 Antibodies (103) and SMURF1 Proteins (5) and many more products for this protein.
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results reveal the regulatory circuit between RUNX2 (show RUNX2 ELISA Kits) and SMURF1 controls RUNX2 (show RUNX2 ELISA Kits) expression and regulates odntoblastic differentiation in hDPSCs.
EGF (show EGF ELISA Kits)/Smurf1 inhibits Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 ELISA Kits).
a model that CD166 (show ALCAM ELISA Kits) regulates MCAM (show MCAM ELISA Kits) through a signaling flow from activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and c-Raf (show RAF1 ELISA Kits)/MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling to the inhibition of potential MCAM (show MCAM ELISA Kits) ubiquitin E3 ligases, betaTrCP (show BTRC ELISA Kits) and Smurf1.
SND1 (show SND1 ELISA Kits) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA ELISA Kits) ubiquitination and degradation.
NF-kappaB (show NFKB1 ELISA Kits) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.
Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.
The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (show CD44 ELISA Kits)(high) expressing.
Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 and Smurf2 genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.
Fbxo3 (show FBXO3 ELISA Kits) promotes the proteasomal degradation of Smurf1. Fbxo3 (show FBXO3 ELISA Kits) promotes the poly-ubiquitination of Smurf1.
TRIB2 (show TRIB2 ELISA Kits) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC ELISA Kits)), COP1 (show CARD16 ELISA Kits) and Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4 (show TCF4 ELISA Kits)/beta-Catenin (show CTNNB1 ELISA Kits) expression, and these effects could be enhanced by TRIB2 (show TRIB2 ELISA Kits).
Smurf1 mediates NGF (show NGFB ELISA Kits) signaling and ubiquitinates RhoA (show RHOA ELISA Kits) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (show PTCH1 ELISA Kits) is required in sonic hedgehog (show SHH ELISA Kits) signal reception
Inhibition of rhBMP-2-induced ALP activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 ELISA Kits) negatively regulates Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
These results suggest that the JNK (show MAPK8 ELISA Kits)/AP-1 (show JUN ELISA Kits) and ERK (show EPHB2 ELISA Kits)/Runx2 (show RUNX2 ELISA Kits) signaling pathways mediate TNF-alpha (show TNF ELISA Kits)-dependent Smurf1 transcription.
Smurf1 is a negative feedback regulator for IFN-gamma (show IFNG ELISA Kits) signaling by targeting STAT1 (show STAT1 ELISA Kits) for ubiquitination and proteasomal degradation.
studies uncover a cell-cycle-independent function of Cdh1 (show CDH1 ELISA Kits), establishing Cdh1 (show CDH1 ELISA Kits) as an upstream component that governs Smurf1 activity
ER stress induces Smurf1 degradation and WFS1 (show WFS1 ELISA Kits) up-regulation
Smurf1 negatively regulates mesenchymal stem cell proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway.
induction could trigger downregulation of bone morphogenetic protein signaling and cause vascular cell proliferation and remodeling in pulmonary arterial hypertension pulmonary arterial hypertension
Data demonstrate that Smurf1 and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1