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SMURF2 Proteins

(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

recommended

SMURF2 Protein (AA 1-748) (Strep Tag) (ABIN3095583)

Crystallography grade SMURF2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB

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recommended

SMURF2 Protein (AA 1-748) (Strep Tag) (ABIN3130681)

Crystallography grade SMURF2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB

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recommended

SMURF2 Protein (AA 1-748, full length) (GST tag) (ABIN5711831)

SMURF2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS

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SMURF2 Proteins by Grade

Find SMURF2 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Proteins by Origin

Find SMURF2 Proteins for a variety of species such as anti-Human SMURF2, anti-Mouse SMURF2. The species listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Proteins by Source

Here you will find SMURF2 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

SMURF2 Proteins by Protein Type

Here you can find SMURF2 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

SMURF2 Proteins by Application

Find SMURF2 Proteins validated for a specific application such as SDS, ELISA, WB, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular SMURF2 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

SMURF2 Protein (AA 1-748) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3095583

Quantity 1 mg

Datasheet Datasheet

SMURF2 Protein (AA 1-748) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3130681

Quantity 1 mg

Datasheet Datasheet

SMURF2 Protein (AA 1-748, full length) (GST tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN5711831

Quantity 100 μg

Datasheet Datasheet

SMURF2 Protein (AA 1-748, full length) (His tag)

Reactivity Human

Source Yeast

Validations

Cat. No. ABIN5714482

Quantity 100 μg

Datasheet Datasheet

SMURF2 Protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2732271

Quantity 20 μg

Datasheet Datasheet

Aliases for SMURF2 Proteins

SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) Proteins
SMAD specific E3 ubiquitin protein ligase 2 (smurf2) Proteins
SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) Proteins
SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) Proteins
2810411E22Rik Proteins
AI558114 Proteins
AI649275 Proteins
RGD1310067 Proteins
SMURF2 Proteins
wu:fb82a11 Proteins
wu:fc41c02 Proteins

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SMURF2 Proteins by Grade

SMURF2 Proteins by Origin

SMURF2 Proteins by Source

SMURF2 Proteins by Protein Type

SMURF2 Proteins by Application

Popular SMURF2 Proteins

Aliases for SMURF2 Proteins

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