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anti-SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) Antibodies

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping SMC6 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMC6 79677 Q96SB8
SMC6 67241 Q924W5
SMC6 313961  
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Top anti-SMC6 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SMC6 AntibodyTitration: 1.0 µg/mL  Positive Control: MCF7 Whole Cell  SMC6 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to SMC6L1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] SMC6L1 monoclonal antibody (M01), clone 2E6 Western Blot analysis of SMC6L1 expression in HeLa . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated WB SMC6L1 monoclonal antibody (M01), clone 2E6 Western Blot analysis of SMC6L1 expression in HeLa on formalin-fixed paraffin-embedded human placenta (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$463.83
Details
Human Mouse Alkaline Phosphatase (AP) IHC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse FITC IHC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse Biotin IHC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details
Human Mouse PE IHC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$925.83
Details

SMC6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMC6 Antibodies

  1. Human Monoclonal SMC6 Primary Antibody for IHC (p), ELISA - ABIN566368 : Gallego-Paez, Tanaka, Bando, Takahashi, Nozaki, Nakato, Shirahige, Hirota: Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells. in Molecular biology of the cell 2014 (PubMed)

More Antibodies against SMC6 Interaction Partners

Human SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) interaction partners

  1. results uncover a novel role for the Smc5 (show SMC5 Antibodies)/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression

  2. Structural maintenance of chromosomes (SMC (show DYM Antibodies)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5 (show SMC5 Antibodies)/6 complex, are central regulators of chromosome dynamics

  3. Depletion of Smc5 (show SMC5 Antibodies) and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors

  4. Studies indicate that Nse1 (show FAM84A Antibodies) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5 (show SMC5 Antibodies)/6 complex.

  5. the human SMC5 (show SMC5 Antibodies)/6 complex and the SUMO ligase activity of hMMS21 (show NSMCE2 Antibodies) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  6. SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.

  7. SMC5 (show SMC5 Antibodies)/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.

  8. The four non-SMC (show DYM Antibodies) components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 (show NDNL2 Antibodies) protein is part of this complex.

  9. Nse1 (show FAM84A Antibodies) RING-like motif is a protein-protein interaction domain required for Smc5 (show SMC5 Antibodies)-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions

Mouse (Murine) SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6) interaction partners

  1. Smc6 has a role in the prevention of aberrant recombination events between pericentromeric regions during the first meiotic prophase.

  2. Mice deleted for the SMC6 gene are inviable, and mice mutated at Ser (show SIGLEC1 Antibodies)-994 in the SMC6 ATPase (show DNAH8 Antibodies) domain have a mild phenotype.

SMC6 Antigen Profile

Protein Summary

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).

Gene names and symbols associated with SMC6

  • structural maintenance of chromosomes 6 (SMC6) antibody
  • SMC6 protein (smc6) antibody
  • structural maintenance of chromosomes 6 (Smc6) antibody
  • 2810489L22Rik antibody
  • 3830418C19Rik antibody
  • AA990493 antibody
  • AU018782 antibody
  • AW742439 antibody
  • hSMC6 antibody
  • mKIAA4103 antibody
  • SMC-6 antibody
  • Smc6l1 antibody

Protein level used designations for SMC6

SMC6 structural maintenance of chromosomes 6-like 1 , SMC protein 6 , structural maintenance of chromosomes protein 6 , mSMC6

GENE ID SPECIES
421950 Gallus gallus
446077 Takifugu rubripes
79677 Homo sapiens
67241 Mus musculus
475675 Canis lupus familiaris
100517523 Sus scrofa
510381 Bos taurus
313961 Rattus norvegicus
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