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Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping SMC6 Proteins (4) and many more products for this protein.
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Human Monoclonal SMC6 Primary Antibody for IHC (p), ELISA - ABIN566368
Gallego-Paez, Tanaka, Bando, Takahashi, Nozaki, Nakato, Shirahige, Hirota: Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells. in Molecular biology of the cell 2014
results uncover a novel role for the Smc5 (show SMC5 Antibodies)/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression
Structural maintenance of chromosomes (SMC (show DYM Antibodies)) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5 (show SMC5 Antibodies)/6 complex, are central regulators of chromosome dynamics
Depletion of Smc5 (show SMC5 Antibodies) and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors
Studies indicate that Nse1 (show FAM84A Antibodies) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5 (show SMC5 Antibodies)/6 complex.
the human SMC5 (show SMC5 Antibodies)/6 complex and the SUMO ligase activity of hMMS21 (show NSMCE2 Antibodies) are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells
SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.
SMC5 (show SMC5 Antibodies)/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.
The four non-SMC (show DYM Antibodies) components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 (show NDNL2 Antibodies) protein is part of this complex.
Nse1 (show FAM84A Antibodies) RING-like motif is a protein-protein interaction domain required for Smc5 (show SMC5 Antibodies)-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions
Smc6 has a role in the prevention of aberrant recombination events between pericentromeric regions during the first meiotic prophase.
Mice deleted for the SMC6 gene are inviable, and mice mutated at Ser (show SIGLEC1 Antibodies)-994 in the SMC6 ATPase (show DNAH8 Antibodies) domain have a mild phenotype.
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).
SMC6 structural maintenance of chromosomes 6-like 1
, SMC protein 6
, structural maintenance of chromosomes protein 6