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SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. Additionally we are shipping and and many more products for this protein.
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Human Monoclonal SHPRH Primary Antibody for WB - ABIN2453839
Zeman, Lin, Freire, Cimprich: DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. in The Journal of cell biology 2014
HLTF (show HLTF Antibodies) and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.
SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region.
SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans
We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress.
HLTF (show HLTF Antibodies) and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA (show PCNA Antibodies) polyubiquitination and maintain genomic stability.
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006
E3 ubiquitin-protein ligase SHPRH
, SNF2, histone-linker, PHD and RING finger domain-containing helicase