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SNURF encodes a highly basic protein localized to the nucleus. Additionally we are shipping SNRPN Upstream Reading Frame Antibodies (8) and SNRPN Upstream Reading Frame Proteins (7) and many more products for this protein.
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significant IGF2 hypermethylation (20 +/- 10 vs. 14 +/- 7%; p<0.05) and SNURF (show RNF4 ELISA Kits) hypomethylation (23 +/- 6 vs. 32 6%; p<0.001) was found in Albright's hereditary osteodystrophy patients vs. controls.
The SNURF-SNRPN sense/UBE3A (show ube3a ELISA Kits) antisense transcription unit spans more than 460 kb.
Identification of cis (show CISH ELISA Kits)- and trans-acting regulatory elements within the endogenous SNURF-SNRPN locus.
the ATG-to-AAG mutation causes a 15-fold or more increase in translation of the downstream ORF in two fusion constructs, and it is likely that similar translational control affects the normal Snurf-Snrpn transcript as well
These data indicate that oocytes undergo time-dependent demethylation of Snrpn (show SNRPN ELISA Kits) differentially methylated regions during the process of postovulatory aging.
This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.
SNRPN upstream reading frame
, SNRPN upstream reading frame protein
, small nuclear ribonucleoprotein N