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SPEG encodes a protein with similarity to members of the myosin light chain kinase family. Additionally we are shipping SPEG Antibodies (16) and many more products for this protein.
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SPEG is present in cardiac muscle, where it plays a critical role; therefore, individuals with SPEG mutations additionally present with dilated cardiomyopathy.
Genomic rearrangement on APEG1 in arteriosclerosis was studied.
the RGD motif might play a role not only in the adhesion of Aortic Preferentially Expressed Protein-1 and extracellular proteins but also in intracellular protein (show CKAP2 Proteins)-protein interactions
Acute loss of SPEG in hearts causes junctophilin-2 (show JPH2 Proteins) de-phosphorylation leading to heart failure.
Disruption of the striated (show NSDHL Proteins) preferentially expressed gene (Speg) locus leads to cardiac dysfunction and a phenotype consistent with dilated cardiomyopathy.
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined.
aortic preferentially expressed gene 1
, novel serine/threonine protein kinase
, striated muscle preferentially expressed protein kinase
, aortic preferentially expressed protein 1
, nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury
, striated muscle-specific serine/threonine-protein kinase