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SOX10 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX10 Proteins (11) and SOX10 Kits (2) and many more products for this protein.
Showing 10 out of 208 products:
Human Monoclonal SOX10 Primary Antibody for IHC (p), ELISA - ABIN520385
Kim, Chang, Yeo, Haw, Kim: Histopathological study of the treatment of melasma lesions using a low-fluence Q-switched 1064-nm neodymium:yttrium-aluminium-garnet laser. in Clinical and experimental dermatology 2013
Show all 2 references for ABIN520385
Human Polyclonal SOX10 Primary Antibody for IHC, IHC (p) - ABIN4355204
Ivanov, Panaccione, Nonaka, Prasad, Boyd, Brown, Guo, Sewell, Yarbrough: Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. in British journal of cancer 2013
Show all 2 references for ABIN4355204
Human Polyclonal SOX10 Primary Antibody for IHC (p), WB - ABIN610607
Hunt, Morimoto: Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. in Proceedings of the National Academy of Sciences of the United States of America 1985
Show all 2 references for ABIN610607
Human Monoclonal SOX10 Primary Antibody for IHC, ELISA - ABIN1724912
Bannykh, Stolt, Kim, Perry, Wegner: Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. in Journal of neuro-oncology 2006
Show all 2 references for ABIN1724912
Human Monoclonal SOX10 Primary Antibody for FACS, ELISA - ABIN1724911
Shin, Vincent, Cuda, Xu, Kang, Kim, Taube: Sox10 is expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytoses. in Journal of the American Academy of Dermatology 2012
Show all 2 references for ABIN1724911
Human Polyclonal SOX10 Primary Antibody for IHC (p), WB - ABIN652035
Li, Tsuneki, Krauthammer, Couture, Schwartz, Madri: Modulation of Sox10, HIF-1?, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. in The American journal of pathology 2015
Study provides evidence that the tumor suppressor Fbxw7alpha is the E3 ubiquitin ligase (show MUL1 Antibodies) responsible for the degradation of SOX10, and suggests that reduced Fbxw7alpha might contribute to the upregulation of SOX10 in melanoma cells.
Sox10 is expressed in many ovarian carcinomas
we demonstrated that SOX10 is one of the most consistent markers of CD133+ stem-like ACC (show ACACA Antibodies) cells. Expression of SOX10 is also seen in other cancers, suggesting that they may contain similar stem-like cells.
Despite the fact that the E248fs has a dominant-negative effect on SOX10, its reduced stability may down-regulate the transcription of MITF (show MITF Antibodies) and decrease the synthesis of melanin
SOX10-positivity rules out the diagnosis of ependymoma among other glial tumors with high confidence
SOX-10 expression is exclusively specific for all cases of metastatic melanoma.
Our study shows an inversed preferential nuclear expression of SLUG (show SNAI2 Antibodies), SOX10, and SOX9 (show SOX9 Antibodies) in triple negative and non-triple negative cases.
SOX10 mutations can mimic non-syndromic hearing impairment.
our data imply that the same SOX10 mutations can underlie both typical Waardenburg syndrome and Kallmann Syndrome with deafness without skin/hair hypopigmentation, Hirschsprung disease, or neurological defects
Subnuclear re-localization of SOX10 and p54NRB (show NONO Antibodies) correlates with a unique neurological phenotype associated with SOX10 missense mutations.
The activity of Sox-10 transcription factor is well conserved and is regulated by SUMOylation.
Kaiso (show ZBTB33 Antibodies) and Sox10 sequentially interact with Tcf7l2 (show TCF7L2 Antibodies) to coordinate the maturation of oligodendrocyte.
Findings uncover a central role of SOX10 as a global regulator of gene expression in the melanocyte lineage by targeting diverse regulatory pathways.
Ets1 (show ETS1 Antibodies) and Sox10 interact to promote proper melanocyte and enteric ganglia development from the neural crest.
Sox10(rtTA/+) driven reporter expression in the cochlea persists for at least 54 days after cessation of neonatal induction
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.
Our findings provide proof-of-concept that Sox10 can convert conducive cells into oligodendrocyte-like cells in vivo and delineates options for future therapeutic strategies.
Conditional deletion of the neural crest specific transcription factor, Sox10, using the rhombic lip/neural crest specific Wnt1 (show WNT1 Antibodies)-cre driver spares Sox10 expression in the ear.
This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 (show EGR2 Antibodies) during myelination
Decreases in Sox10 expression levels and a loss of Sox10(+) cells in both mouse and human aged ears suggests an important role of Sox10 in the maintenance of structural and functional integrity of the lateral wall.
SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland.
Demonstrate a contribution of sox10-dependent cranial neural crest to olfactory sensory neurons in zebrafish and provide important insights into the assembly of the nascent olfactory system.
Data indicate that the optical flow analysis detected and quantified significant differences in the cell migrations of Sox10:EGFP positive cranial neural crest cells in ethanol treated versus untreated embryos.
Sox10 might not be required for neural crest formation but is important for later steps during neural crest development.
prdm1a (show PRDM1 Antibodies) Regulates sox10 and islet1 (show ISL1 Antibodies) in the development of neural crest and Rohon-Beard sensory neurons.
Sox10 function is necessary for the survival of myelinating oligodedrocytes subsequent to axon wrapping but is not required for the survival of nonmyelinating oligodendrocyte progenitor cells.
Phox2b (show PHOX2B Antibodies) function is sox10-dependent in the developing enteric nervous system
Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.
Data show that expression of Mitf (show MITF Antibodies) rescues pigmentation fully in zebrafish, but only partially in Sox10-mutant mice.
Sox10 is expressed transiently in the sensory neuron lineage, and specifies sensory neuron precursors by regulating the proneural gene neurogenin1 (show NEUROG1 Antibodies).
Sox10 has diverse roles in the otic vesicle that may be important in a zebrafish model for Waardenburg syndrome type IV
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
, SRY (sex determining region Y)-box 10
, transcription factor Sox-10
, transcription factor SOX-10-like
, transcription factor sox10
, SRY-related HMG-box gene 10
, dominant megacolon, mouse, human homolog of
, transcription factor SOX-10
, SRY-box containing gene 10
, Sry-boxntranscription factor, SOX-10
, SRY-box 10
, transcription factor Sox10
, dominant megacolon
, transcription factor SOX-M