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SRY (Sex Determining Region Y)-Box 17 Proteins (SOX17)

SOX17 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX17 Antibodies (85) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX17 64321 Q9H6I2
Rat SOX17 SOX17 312936  
SOX17 20671 Q61473
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Top SOX17 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SOX17 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 17 (SOX17) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Knockdown of OCT4 (show POU5F1 Proteins) during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 promoter, suggesting that OCT4 (show POU5F1 Proteins) acts to induce removal of the Polycomb2 complex.

  2. high expression of the Sox17 associated pathway in medium and small arteries indicates that Brain arteriovenous malformation vessels are intrinsically active

  3. SOX17 demethylation induced miR (show MLXIP Proteins)-371-5p expression and consequently suppressed its direct target SOX2 (show SOX2 Proteins). A novel mechanism of the SOX17/miR (show MLXIP Proteins)-371-5p/SOX2 (show SOX2 Proteins) axis is involved in the regulation of EMT (show ITK Proteins), stemness and metastasis.

  4. Decreased expression of SOX17 is associated with tumor progression in breast cancer.

  5. In this study, oligodendroglioma patients with 1p/19q LOH and Sox17 protein expression had a better prognosis.

  6. SOX17 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.

  7. Decreased Sox17 expression is correlated with melanoma progression, an unfavorable survival of melanoma patients and is an independent molecular prognostic factor for melanoma.

  8. Possible association of SOX-17 and RBBP8 (show RBBP8 Proteins) with brain arteriovenous malformations, genes involved in cell cycle progression, deserves further investigation

  9. Human intracranial aneurysm samples showed reduced Sox17 expression and impaired endothelial integrity.

  10. Low Sox17 expression is associated with hepatocellular carcinoma.

Zebrafish SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. Targeted knockdown of Sox17 and Chd (show CHRD Proteins) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Proteins), and heart and pancreas placement in the embryo.

  2. knockout of dusp4 (show DUSP4 Proteins) revealed a specific loss of sox17, establishing a new class of endoderm specification defect

  3. Results describe sox17 cis (show CISH Proteins)-regulatory elements, and examine the specific input predictions of the gene regulatory networks.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 17 (SOX17) interaction partners

  1. combined deletion of Sox7 (show SOX7 Proteins), Sox17, and Sox18 (show SOX18 Proteins) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity

  2. Sox17 inhibition of Runx1 (show RUNX1 Proteins) and Gata2 (show GATA2 Proteins) maintains endothelial fate in endothelial-to-haematopoietic transition

  3. Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation.

  4. These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting.

  5. the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut (show GUSB Proteins) endoderm morphogenesis and the assembly of the basement membrane that separates gut (show GUSB Proteins) endoderm from mesoderm.

  6. Hhex (show HHEX Proteins) and Cer1 (show CER1 Proteins) are indispensable components of the Sox17 pathway for cardiopoiesis.

  7. A regulatory network, incluing Sox17 and the retinoic acid receptor (show RARA Proteins), controls nephrocan expression and midgut patterning.

  8. Sox17 promotes endothelial migration. It destabilizes endothelial junctions, rearranges the cytoskeleton, and upregulates several genes expressed in tip cells. The Notch (show NOTCH1 Proteins) pathway regulates Sox17 expression mainly at the post-transcriptional level.

  9. SoxF proteins, especially Sox17, contribute to the maintenance of cell clusters containing hematopoietic stem cells in the midgestation aorta-gonad-mesonephros region

  10. Sox17 is a component of the complex signaling network that orchestrates arterial/venous specification.

SOX17 Protein Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

Gene names and symbols associated with SOX17

  • SRY (sex determining region Y)-box 17 beta, gene 1 (sox17b.1)
  • SRY (sex determining region Y)-box 17 alpha (sox17a)
  • SRY (sex determining region Y)-box 17 (SOX17)
  • similar to SRY-box 17 (SOX17)
  • SRY (sex determining region Y)-box 17 beta, gene 2 (sox17b.2)
  • SRY-box containing gene 17 (sox17)
  • sox7/17 protein (sox7/17)
  • SRY (sex determining region Y)-box 17 (Sox17)
  • SRY-box containing gene 17 (Sox17)
  • Sox protein
  • sox7/17 protein
  • SOX17 protein
  • sox17-alpha protein
  • sox17-beta protein
  • Sox17alpha protein
  • sox17beta protein
  • tSox17alpha protein
  • tSox17beta protein
  • VUR3 protein
  • Xsox17 protein
  • Xsox17-alpha protein
  • Xsox17-beta protein
  • xsox17a protein
  • Xsox17alpha protein
  • xSox17alpha1 protein
  • xSox17alpha2 protein

Protein level used designations for SOX17

SRY (sex determining region Y)-box 17 beta, gene 1 , Transcription factor Sox-17-beta.1 , HMG box transcription factor Sox17-beta , SRY (sex determining region Y)-box 17-beta.1 , HMG box transcription factor Sox17-alpha , sox17 alpha , transcription factor Sox-17-alpha , SRY (sex determining region Y)-box 17 , similar to SRY-box 17 , SRY (sex determining region Y)-box 17 beta, gene 2 , Transcription factor Sox-17-beta.2 , SRY (sex determining region Y)-box 17-beta.2 , SRY-box containing gene 17 , sox7/17 protein , SRY-related HMG-box transcription factor SOX17 , transcription factor SOX-17 , HMG transcription factor SOX17 , SRY-box 17

GENE ID SPECIES
394440 Xenopus (Silurana) tropicalis
395066 Xenopus (Silurana) tropicalis
694097 Macaca mulatta
695494 Macaca mulatta
740572 Pan troglodytes
100038235 Xenopus (Silurana) tropicalis
100304455 Oryzias latipes
100591356 Nomascus leucogenys
100303486 Saccoglossus kowalevskii
64321 Homo sapiens
486955 Canis lupus familiaris
312936 Rattus norvegicus
428534 Gallus gallus
534010 Bos taurus
30544 Danio rerio
20671 Mus musculus
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