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SOX3 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX3 Antibodies (64) and SOX3 Kits (26) and many more products for this protein.
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SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation.
Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY (show SRY Proteins) in some XX subjects
Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary
Our study provides additional evidence that deletion in polyalanine tracts of SOX3 is associated with hypopituitarism
SOX3 duplication is a genetic cause for XH but has incomplete penetrance. Moreover, increased SOX3 levels may be a risk factor for NTD and potentially other clinical characteristics.
the results point at CREB (show CREB1 Proteins) as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent.
Overexpression of Sox3 is associated with esophageal squamous cell carcinoma.
Data indicate that HESX1 (show HESX1 Proteins), LHX4 (show LHX4 Proteins) and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
Results indicate positive expression of SOX2, SOX3, PAX6, OCT3/4, and NANOG in the CD105+ and CD105(-) cell subpopulations.
TGIF (TG-interacting factor (show TGIF1 Proteins)) is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression
Sox2 (show SOX2 Proteins) is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2 (show SOX2 Proteins)/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
XSeb4R (show RBM38 Proteins) protein bound specifically to the 3'UTR of Sox3 mRNA. XSeb4R (show RBM38 Proteins) gain-of-function in ectodermal explants revealed increased stability of the maternal Sox3 transcripts, associated with a robust Sox3 protein production.
knockdown of Oct91 inhibits neural induction driven by either Sox2 (show SOX2 Proteins) or Sox3.
Animal pole localized Sox3 acts to inhibit Nodal (Xnr5 and Xnr6) expression, and induces the expression of genes (Ectodermin (show TRIM33 Proteins), Xema (show FOXI1 Proteins), and Coco (show DAND5 Proteins)) whose products repress Nodal signaling.
Results demonstrate that both sox3 and sox2 are induced in response to BMP antagonism, but by distinct mechanisms and that the activation of both genes is independent of FGF signaling; however, both require FGF for the maintenance of their expression.
Eya1 (show EYA1 Proteins) and Six1 (show SIX1 Proteins) are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
Sox3 null mice exhibit a ventral extension of the anterior pituitary that penetrates, and generates a mass beneath, the sphenoid bone
These data define Dbx1 (show DBX1 Proteins) as a direct SOX3 target gene.
Sox2 (show SOX2 Proteins) and Sox3 play a role in central nervous system glia and provide mechanistic insights into their function during differentiation processes.
findings show SOX3 expression is maintained throughout telencephalic neurogenesis and is restricted to progenitor cells with neuroepithelial and radial glial morphologies; it is expressed within adult neurogenic regions; expression within the developing hypothalamus is upregulated in developing neurons and is maintained in a subset of differentiated hypoththalamic cells
Subcommissural organ function is essential for the prevention of hydrocephalus and overexpression of Sox3 in the dorsal midline alters progenitor cell differentiation in a dose-dependent manner.
It was shown that Sox2 (show SOX2 Proteins) and Sox3 are dose-dependent regulators of sonic hedgehog (show SHH Proteins) transcription that directly bind and activate a long-range Shh (show SHH Proteins) forebrain enhancer.
In neural precursor cells , Sox3 binds genes that are later bound and activated by Sox11 (show SOX11 Proteins) in differentiating neurons (Sox2 (show SOX2 Proteins))
The results indicate that Sox3 functions in an intrinsic manner to promote differentiation of spermatogonia in prepubertal mice but it is not required for ongoing spermatogenesis in adults.
in a transgenic line, Sox3 was ectopically expressed in the bipotential gonad and this led to frequent complete XX male sex reversal
Sox3 is not required for gonadal determination but is important for normal oocyte development and male testis differentiation and gametogenesis.
significant decreases in sox3 (up to 3-fold) expression following chilling. Significant increases in expression of sox3 (up to 33-fold) during warming of chilled zebrafish embyos.
Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development
Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2 (show SOX2 Proteins)/3/19a/19b resulted in severe developmental abnormalities.
The pro-neural effects of Sox3 can compensate for inhibition of fibroblast growth factor (Fgf) signalling in inducing neural tissue but it is not sufficient to maintain neural fate, suggesting the presence of Sox3-independent roles of Fgf at later stages.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
transcription factor SOX-3
, transcription factor Sox-3
, SRY (sex determining region Y)-box 3
, SRY-related protein CH3
, transcription factor SOX3
, transcription factor Sox-3-A