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SOX7 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX7 Proteins (6) and many more products for this protein.
Showing 10 out of 49 products:
Human Polyclonal SOX7 Primary Antibody for IHC, WB - ABIN2778378
Colland, Jacq, Trouplin, Mougin, Groizeleau, Hamburger, Meil, Wojcik, Legrain, Gauthier: Functional proteomics mapping of a human signaling pathway. in Genome research 2004
Human Polyclonal SOX7 Primary Antibody for WB - ABIN2779969
Wilson, Yang, Kalousova, Lau, Kosaka, Lynn, Wang, Mrejen, Episkopou, Clevers, German: The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. in Diabetes 2005
the HMG (show SSRP1 Antibodies)-box is a key domain of SOX7 for negatively regulating the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway when functioning as a tumor suppressor in a glioma.
The results provided unequivocal evidence for a novel tumor suppressor role of SOX7 in acute myeloid leukemia (show BCL11A Antibodies)
SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for hepatocellular carcinoma therapy.
Ectopic expression of miR (show MLXIP Antibodies)-492 led to downregulation of SOX7 protein.
Low SOX7 expression is associated with hepatocellular carcinoma.
The expression of SOX7 correlates with tumor progression as a tumor suppressor, possibly through the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway in ovarian cancers, suggesting that SOX7 may be a promising prognostic marker.
Decreased expression of Sox7 correlates with the upregulation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway and the poor survival of gastric cancer patients.
miR (show MLXIP Antibodies)-184 represents a potential onco-miR (show MLXIP Antibodies) and plays an important role in HCC (show FAM126A Antibodies) progression by suppressing SOX7 expression
SOX7 acts as a tumor suppressor in breast cancer.
SOX7 is a novel tumor suppressor gene silenced in the majority of NSCLC samples.
SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo
SOX7 and SOX18b are essential regulators of cardiogenesis in Xenopus.
Vegetal pole localized Sox7 positively regulates Nodal (Xnr4, Xnr5, and Xnr6) expression, as well as the expression of genes involved in mesodermal (Xmenf, Slug, and Snail) and endodermal (Endodermin and Sox17beta) differentiation.
combined deletion of Sox7, Sox17 (show SOX17 Antibodies), and Sox18 (show SOX18 Antibodies) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (show SOX17 Antibodies) allele largely restores arterial identity
These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system.
ETV2 (show ETV2 Antibodies) directly regulates Sox7, and ETV2 (show ETV2 Antibodies) governs endothelial development by regulating transcriptional networks which include Sox7.
Notch and SoxF factors combinatorially regulate Dll4 expression in arteries downstream of VEGF.
Haploinsufficiency of Sox7 or Gata4 (show GATA4 Antibodies) is sufficient to produce anterior congenital diaphragmatic hernia in mice.
SOX7 regulates the expression of VE-cadherin (show CDH5 Antibodies) in the haemogenic endothelium at the onset of haematopoietic development.
Sox7-sustained expression in the earliest committed hematopoietic precursors promotes the maintenance of their multipotent and self-renewing status.
SOX7 and GATA-4 (show GATA4 Antibodies) are competitive activators of Fgf-3 (show FGF3 Antibodies) transcription
SOX7 and SOX17 (show SOX17 Antibodies) bound specifically to two SOX (show QSOX1 Antibodies)-binding sites within the Lama1 (show LAMA1 Antibodies) enhancer, and that these SOX (show QSOX1 Antibodies)-binding sites functioned synergistically to confer the trans-activation by SOX7 and SOX17 (show SOX17 Antibodies)
is required for the induction of Gata-4 (show GATA4 Antibodies) and Gata-6 (show GATA6 Antibodies), and the interplay among these transcription factors plays a crucial role in parietal endoderm differentiation
Sox7 levels are crucial in arterial specification in conjunction with hey2 (show HEY2 Antibodies) and efnb2 (show EFNB2 Antibodies) function, with mutants in all three genes displaying shunt formation and an arterial block.
Sox7/18 factors and Notch (show NOTCH1 Antibodies) regulate nr2f2 (show NR2F2 Antibodies) gene expression during venous differentiation in zebrafish.
Sox7 and Sox18 (show SOX18 Antibodies)-mediated transcriptional regulation of Robo4 (show ROBO4 Antibodies) is important in the developing embryonic vasculature
Sox7 and sox18 (show SOX18 Antibodies) are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
Sox7 and sox18 (show SOX18 Antibodies) play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
Sox7 and Sox18 (show SOX18 Antibodies) control arterial-venous identity by regulating Gridlock (show HEY2 Antibodies) expression.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
transcription factor SOX-7
, SRY-box containing gene 7
, SRY (sex determining region Y)-box 7, xSox7 protein
, transcription factor Sox-7
, SRY (sex determining region Y)-box 7