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SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). Additionally we are shipping SOX21 Antibodies (40) and many more products for this protein.
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We further demonstrate that JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling, Sox21a and GATAe form a functional relay to orchestrate EB differentiation. Thus, our study provides new insights into the complex and sequential events that are required for rapid differentiation following stem cell division during tissue replenishment.
Sox21a is specifically required for adult intestinal stem cell proliferation.
This study reports that loss of the SOX (show PIPOX Proteins) transcription factor, Sox21a, blocks the differentiation programme of enteroblast (EB), the intestinal stem cell progeny in the adult Drosophila midgut with subsequent tumor formation.
Tumors originating from glioma cells with an induced expression of Sox21 exhibited an increased formation of Sox2 (show SOX2 Proteins):Sox21 complexes and an upregulation of S100beta, CNPase (show CNP Proteins) and Tuj1
suggest that Sox21 can negatively regulate Sox2 (show SOX2 Proteins) in glioma. Our findings imply that Sox2 (show SOX2 Proteins) and Sox21 may be interesting targets for the development of novel glioma therapy
Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner.
Following elevation of the palatal shelves (E14.5), Sox2 (show SOX2 Proteins), Sox11 (show SOX11 Proteins) and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox (show QSOX1 Proteins) gene family during the process of palatogenesis
Study identifies CARM1 (show CARM1 Proteins), which methylates histone H3 (show HIST3H3 Proteins) at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.
results implicate Sox21 specifically in the promotion of spongiotrophoblast and giant cell differentiation and establish a new mechanism through which trophoblast sublineages are specified
The effects of Sox21 gene deletion on hair lipids have been studied.
results show that transcriptional induction of Sox21 is a rapid and general mediator of the effects of Sox2 (show SOX2 Proteins) on cell identity in a wide range of cell types
Sox21 repressed Hes5 (show HES5 Proteins) gene expression at the transcriptional level in hippocampus adult neurogenesis.
Sox21, a counteracting partner of the SoxB1 family, controls fine-tuned cell fate decisions
Findings suggest that bivalent genes, such as Sox21, are silenced by a complex set of redundant repressive machinery, which exit rapidly in response to appropriate differentiation signals.
Data show that ectopic expression of Sox21 in ESC induces their differentiation into specific cell types, including those that express markers representative of neurectoderm and heart development.
Overexpression of Sox21 results in a substantial repression of NGF (show NGFB Proteins)-induced neurite outgrowth in PC12 cells. Y-box binding protein 1 (show YBX1 Proteins) not only binds to Sox21 but also partially restores NGF (show NGFB Proteins)-induced neurite outgrowth of PC12 cells inhibited by Sox21.
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).
, SRY (sex determining region Y)-box 21
, SRY-box containing gene 21
, SRY-box 21
, transcription factor SOX-21
, transcription factor Sox-21
, DNA-binding protein SOX21
, HMG-box protein SOX21