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ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Proteins (ST8SIA4)

The protein encoded by ST8SIA4 catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). Additionally we are shipping ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Antibodies (37) and ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ST8SIA4 7903 Q92187
ST8SIA4 20452 Q64692
Rat ST8SIA4 ST8SIA4 116696  
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Top ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,979.17
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,979.17
Details

ST8SIA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaction Partners

Human ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. ST8SIA4 gene is involved in the development of multidrug resistance via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway in chronic myeloid leukemia (show BCL11A Proteins).

  2. this study indicated that sialylation involved in the development of MDR of AML (show RUNX1 Proteins) cells probably through ST3GAL5 (show ST3GAL5 Proteins) or ST8SIA4 regulating the activity of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling and the expression of P-gp (show ABCB4 Proteins) and MRP1 (show MDM4 Proteins).

  3. ST8SiaIV synthesized polySia selectively on a NRP2 (show NELL2 Proteins) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

  4. The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition.

  5. polysialylated NCAM (show NCAM1 Proteins) persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein (show MAG Proteins) may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy

  6. SIAT8D has a role in neural development and sialic acid synthesis on NCAM (show NCAM1 Proteins)

  7. Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR (show CFTR Proteins)) and acini (PST1) indicating that PST1 is a modifier gene for CFTR (show CFTR Proteins)-related idiopathic chronic pancreatitis.

  8. The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 (show ST8SIA2 Proteins) by valproic acid in HUVEC and tumor cell lines are reported.

  9. polysialyltransferase ST8Sia IV/PST recognizes specific amino acids in the first fibronectin (show FN1 Proteins) type III repeat of the neural cell adhesion molecule (show MCAM Proteins)

  10. PSA (show PLAG1 Proteins)-NCAM (show NCAM1 Proteins) and ST8Sia-II (show ST8SIA2 Proteins)/IV Expression Is Increased in Pancreatic Carcinomas

Pig (Porcine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. Pig cDNA provides a basis for uncovering the roles of ST8Sia IV during piglet development and maturation.

Mouse (Murine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. SULT1A1 (show SULT1A1 Proteins) is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.

  2. NCAM (show NCAM1 Proteins)-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM (show NCAM1 Proteins)-140 catalyzed by STX (show ST8SIA2 Proteins), but not by PST, enhanced NCAM (show NCAM1 Proteins)-mediated cell migration, but not cell proliferation or motility.

  3. ST8SiaIV synthesized polySia selectively on a NRP2 (show NRP2 Proteins) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

  4. Results indicate that the polySTs ST8SiaII (show ST8SIA2 Proteins) and ST8SiaIV not only recognize an acidic patch in the FN1 (show FN1 Proteins) domain of NCAM (show NCAM1 Proteins) but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

  5. the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration

  6. While both ST8SiaII (show ST8SIA2 Proteins) and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII (show ST8SIA2 Proteins) mRNA level reduction is regulated by sensory experience

  7. ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA (show NPEPPS Proteins)-NCAM (show NCAM1 Proteins) expression in all brain regions analyzed.

  8. This study demonistrated that mice lacking St8siaIV polysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination.

  9. In summary, the data suggest that the polysialic acid-neural cell adhesion molecule (show MCAM Proteins) system is a putative target for the modulation of

  10. Focusing on the cerebral cortex, our results indicate that ST8SiaIV is solely responsible for PSA (show NPEPPS Proteins) expression in mature interneurons and in most regions of cortical neuropil.

ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ST8SIA4

  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4)
  • sulfotransferase family 1A, phenol-preferring, member 1 (Sult1a1)
  • AI266890 protein
  • PST protein
  • PST-1 protein
  • PST1 protein
  • SIAT8-D protein
  • Siat8d protein
  • ST1A1 protein
  • ST8Sia-IV protein
  • ST8SiaIV protein
  • Stp protein
  • Stp1 protein

Protein level used designations for ST8SIA4

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase , sialyltransferase 8D (alpha-2, 8-polysialyltransferase) , CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase , SIAT8-D , ST8SiaIV , alpha-2,8-sialyltransferase 8D , polysialyltransferase-1 , sialyltransferase 8 (alpha-2, 8-polysialytransferase) D , sialyltransferase 8D , sialyltransferase St8Sia IV , sialytransferase St8Sia IV , alpha-2,8-polysialyltransferase IV , ST8Sia IV , sialyltransferase 8 (alpha-2, 8-sialyltransferase) D , polysialyltransferase , sialyltransferase 8 (alpha-2 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2 8-polysialytransferase) D , sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2, 8-sialytransferase) D , polysialyltransferase 1 , ST1A4 , aryl sulfotransferase , arylsulfotransferase ST1A4 , mSTp1 , phenol sulfotransferase , phenol/aryl sulfotransferase , sulfokinase , sulfotransferase 1A1 , sulfotransferase, phenol preferring 1

GENE ID SPECIES
374155 Gallus gallus
7903 Homo sapiens
488886 Canis lupus familiaris
641356 Sus scrofa
407768 Bos taurus
20452 Mus musculus
116696 Rattus norvegicus
461971 Pan troglodytes
101112314 Ovis aries
20887 Mus musculus
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