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anti-STEAP Family Member 3, Metalloreductase (STEAP3) Antibodies

induces apoptosis; inhibits prostate tumor growth in some cell lines. Additionally we are shipping STEAP Family Member 3, Metalloreductase Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
STEAP3 68428 Q8CI59
STEAP3 55240 Q658P3
STEAP3 170824 Q5RKL5
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Top anti-STEAP Family Member 3, Metalloreductase Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-STEAP3 Antibody Titration: 5.0ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB STEAP3 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35µg/lane).This demonstrates the STEAP3 antibody detected the STEAP3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of STEAP3 in mouse liver tissue with this product at 2.5 μg/ml. Western blot analysis of STEAP3 in rat liver tissue lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB STEAP3 Antibody (C-term)  western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the STEAP3 antibody detected the STEAP3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Pancreas (formalin-fixed, paraffin-embedded) stained with STEAP3 antibody ABIN213986 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of STEAP3 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of STEAP3 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

STEAP3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human , , ,


, , , , ,
Rat (Rattus)


Top referenced anti-STEAP Family Member 3, Metalloreductase Antibodies

  1. Human Polyclonal STEAP3 Primary Antibody for EIA, WB - ABIN954977 : Hanna, Kruskal, Ezekowitz, Bloom, Collier: Role of macrophage oxidative burst in the action of anthrax lethal toxin. in Molecular medicine (Cambridge, Mass.) 1996 (PubMed)
    Show all 2 references for ABIN954977

  2. Human Polyclonal STEAP3 Primary Antibody for WB - ABIN2781298 : Sendamarai, Ohgami, Fleming, Lawrence: Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

  3. Human Polyclonal STEAP3 Primary Antibody for EIA, IHC (p) - ABIN500823 : Ohgami, Campagna, Greer, Antiochos, McDonald, Chen, Sharp, Fujiwara, Barker, Fleming: Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. in Nature genetics 2005 (PubMed)

  4. Human Polyclonal STEAP3 Primary Antibody for WB - ABIN2781309 : Amzallag, Passer, Allanic, Segura, Théry, Goud, Amson, Telerman: TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against STEAP Family Member 3, Metalloreductase Interaction Partners

Mouse (Murine) STEAP Family Member 3, Metalloreductase (STEAP3) interaction partners

  1. TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia.

  2. Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4 (show TLR4 Antibodies)-mediated inflammatory responses in macrophages.

  3. Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.

  4. TSAP6 may augment Myt1 (show MYT1 Antibodies) activity and act downstream to p53 (show TP53 Antibodies) to interface apoptosis and cell-cycle progression

  5. The DNA damage-induced p53 (show TP53 Antibodies)-dependent nonclassical exosomal secretory pathway is abrogated in TSAP6-null cells.

  6. hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))

Human STEAP Family Member 3, Metalloreductase (STEAP3) interaction partners

  1. heterozygous STEAP3 mutations are relatively common in humans and that their deleterious effect in humans remains to be confirmed

  2. TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.

  3. findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition

  4. TSAP6 may augment Myt1 (show MYT1 Antibodies) activity and act downstream to p53 (show TP53 Antibodies) to interface apoptosis and cell-cycle progression

  5. role for TSAP6 in the export of TCTP (show TPT1 Antibodies) and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion.

  6. The crystal structure of the human Steap3 oxidoreductase (show TXNRD1 Antibodies) domain in the absence and presence of NADPH (show NQO1 Antibodies) was determined.

  7. Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma

STEAP Family Member 3, Metalloreductase (STEAP3) Antigen Profile

Protein Summary

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Gene names and symbols associated with STEAP3

  • STEAP family member 3 (STEAP3) antibody
  • STEAP family member 3, metalloreductase (STEAP3) antibody
  • STEAP family member 3 (steap3) antibody
  • STEAP family member 3 (Steap3) antibody
  • STEAP family member 3, metalloreductase (Steap3) antibody
  • 1010001D01Rik antibody
  • AHMIO2 antibody
  • dudlin-2 antibody
  • pHyde antibody
  • STEAP3 antibody
  • STMP3 antibody
  • TSAP6 antibody

Protein level used designations for STEAP3

STEAP family member 3 , dudulin 2 , metalloreductase STEAP3-like , dudulin-2 , metalloreductase STEAP3 , protein nm1054 , six-transmembrane epithelial antigen of prostate 3 , tumor suppressor-activated pathway protein 6 , 1010001D01Rik , dudlin 2 , hTSAP6 , hpHyde , pHyde , six transmembrane prostate protein 3 , tumor suppressor pHyde

GENE ID SPECIES
424275 Gallus gallus
459572 Pan troglodytes
483885 Canis lupus familiaris
504235 Bos taurus
100354683 Oryctolagus cuniculus
100401628 Callithrix jacchus
100427279 Macaca mulatta
100434475 Pongo abelii
100480072 Ailuropoda melanoleuca
100561470 Anolis carolinensis
100604205 Nomascus leucogenys
100620912 Sus scrofa
68428 Mus musculus
55240 Homo sapiens
170824 Rattus norvegicus
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