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STEAP Family Member 3, Metalloreductase (STEAP3) ELISA Kits

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Additionally we are shipping STEAP Family Member 3, Metalloreductase Antibodies (55) and STEAP Family Member 3, Metalloreductase Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse STEAP3 STEAP3 68428 Q8CI59
Anti-Human STEAP3 STEAP3 55240 Q658P3
Anti-Rat STEAP3 STEAP3 170824 Q5RKL5
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More ELISA Kits for STEAP Family Member 3, Metalloreductase Interaction Partners

Mouse (Murine) STEAP Family Member 3, Metalloreductase (STEAP3) interaction partners

  1. TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia.

  2. Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4 (show TLR4 ELISA Kits)-mediated inflammatory responses in macrophages.

  3. Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.

  4. TSAP6 may augment Myt1 (show MYT1 ELISA Kits) activity and act downstream to p53 (show TP53 ELISA Kits) to interface apoptosis and cell-cycle progression

  5. The DNA damage-induced p53 (show TP53 ELISA Kits)-dependent nonclassical exosomal secretory pathway is abrogated in TSAP6-null cells.

  6. hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))

Human STEAP Family Member 3, Metalloreductase (STEAP3) interaction partners

  1. heterozygous STEAP3 mutations are relatively common in humans and that their deleterious effect in humans remains to be confirmed

  2. TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.

  3. findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition

  4. TSAP6 may augment Myt1 (show MYT1 ELISA Kits) activity and act downstream to p53 (show TP53 ELISA Kits) to interface apoptosis and cell-cycle progression

  5. role for TSAP6 in the export of TCTP (show TPT1 ELISA Kits) and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion.

  6. The crystal structure of the human Steap3 oxidoreductase (show TXNRD1 ELISA Kits) domain in the absence and presence of NADPH (show NQO1 ELISA Kits) was determined.

  7. Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma

STEAP Family Member 3, Metalloreductase (STEAP3) Antigen Profile

Antigen Summary

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Gene names and symbols associated with STEAP3

  • STEAP family member 3 (STEAP3) antibody
  • STEAP family member 3, metalloreductase (STEAP3) antibody
  • STEAP family member 3 (steap3) antibody
  • STEAP family member 3 (Steap3) antibody
  • STEAP family member 3, metalloreductase (Steap3) antibody
  • 1010001D01Rik antibody
  • AHMIO2 antibody
  • dudlin-2 antibody
  • pHyde antibody
  • STEAP3 antibody
  • STMP3 antibody
  • TSAP6 antibody

Protein level used designations for STEAP3

STEAP family member 3 , dudulin 2 , metalloreductase STEAP3-like , dudulin-2 , metalloreductase STEAP3 , protein nm1054 , six-transmembrane epithelial antigen of prostate 3 , tumor suppressor-activated pathway protein 6 , 1010001D01Rik , dudlin 2 , hTSAP6 , hpHyde , pHyde , six transmembrane prostate protein 3 , tumor suppressor pHyde

GENE ID SPECIES
424275 Gallus gallus
459572 Pan troglodytes
483885 Canis lupus familiaris
504235 Bos taurus
100354683 Oryctolagus cuniculus
100401628 Callithrix jacchus
100427279 Macaca mulatta
100434475 Pongo abelii
100480072 Ailuropoda melanoleuca
100561470 Anolis carolinensis
100604205 Nomascus leucogenys
100620912 Sus scrofa
68428 Mus musculus
55240 Homo sapiens
170824 Rattus norvegicus
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