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anti-STIP1 Homology and U-Box Containing Protein 1 (STUB1) Antibodies

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008. Additionally we are shipping STIP1 Homology and U-Box Containing Protein 1 Proteins (20) and STIP1 Homology and U-Box Containing Protein 1 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
STUB1 56424 Q9WUD1
STUB1 10273 Q9UNE7
STUB1 287155  
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Top anti-STIP1 Homology and U-Box Containing Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-STUB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Spleen Sample Type: Mouse Brain Slices Red: primaryBlue: DAPIPrimary Dilution: 1:400 Secondary Antibody: Anti-Rabbit IgG Alexa 594Secondary Dilution: 1:400 Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt University of Seville 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB (LEFT)Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CHIP (STUB1) antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (RIGHT)Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-CHIP (STUB1) Antibody (C-term) in Ramos cell line lysates (35ug/lane). CHIP (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow Cytometric analysis of K562 cells using STUB1 / CHIP Antibody (C-term) Cat.-No AP54084PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of STUB1 / CHIP Antibody (C-term) Cat.-No AP54084PU-N  in K562 cell line lysates (35ug/lane). This demonstrates the STUB1 antibody detected the STUB1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Cow Goat Un-conjugated WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Goat Un-conjugated ELISA, WB ABIN184697 staining (0.3µg/ml) of Human Muscle lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-CHIP (STUB1) Antibody (C-term) (ABIN390386) in Ramos cell line lysates (35 µg/lane). CHIP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CHIP (STUB1) antibody (C-term) (ABIN390386), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB STUB1 Antibody (C-term) (ABIN656111) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the STUB1 antibody detected the STUB1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Anti-STUB1 antibody IHC staining of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962686 concentration 41396 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details

STUB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-STIP1 Homology and U-Box Containing Protein 1 Antibodies

  1. Human Polyclonal STUB1 Primary Antibody for EIA, IHC (p) - ABIN359012 : Peng, Morishima, Jenkins, Dunbar, Lau, Patterson, Pratt, Osawa: Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 10 references for ABIN359012

  2. Human Polyclonal STUB1 Primary Antibody for EIA, FACS - ABIN954992 : Stankiewicz, Nikolay, Rybin, Mayer: CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates. in The FEBS journal 2010 (PubMed)
    Show all 3 references for ABIN954992

  3. Cow (Bovine) Polyclonal STUB1 Primary Antibody for EIA, WB - ABIN374173 : Jiang, Ballinger, Wu, Dai, Cyr, Höhfeld, Patterson: CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. in The Journal of biological chemistry 2001 (PubMed)

  4. Chicken Polyclonal STUB1 Primary Antibody for WB - ABIN2774917 : Parsons, Tait, Finch, Dianova, Allinson, Dianov: CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. in Molecular cell 2008 (PubMed)

More Antibodies against STIP1 Homology and U-Box Containing Protein 1 Interaction Partners

Arabidopsis thaliana STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. Through selective degradation of Clp subunits, AtCHIP could positively regulate homeostasis of Clp proteolytic subunits and maximize the production of functional chloroplasts. Similar results were obtained from transgenic tobacco plants.

  2. we propose that CHIP and NBR1 (show NBR1 Antibodies) mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation

  3. Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (show Psmd4 Antibodies) system.

  4. AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]

  5. The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.

Mouse (Murine) STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. PABPN1 (show PABPN1 Antibodies) interacts with and is stabilized by heat shock protein 90 (show HSP90 Antibodies).

  2. CHIP targets Osx (show SP7 Antibodies) for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (show TNF Antibodies).

  3. CHIP/TRAF3 (show TRAF3 Antibodies)/NIK (show MAP4K4 Antibodies) interactions recruit NIK (show MAP4K4 Antibodies) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 Antibodies) at low levels

  4. Cbl-b, together with Stub1, ubiquitinate Foxp3 (show FOXP3 Antibodies), and regulate tTreg development.

  5. CHIP regulates the levels of FMR1 (show FMR1 Antibodies) as an E3 ubiquitin ligase (show MUL1 Antibodies) in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1 (show FMR1 Antibodies)-mediated translational repression by regulating the levels of FMR1 (show FMR1 Antibodies).

  6. The cardiac CHIP appears to play a role in regulating autophagy during the development of cardiac hypertrophy, possibly by its role in supporting Akt (show AKT1 Antibodies) signalling, induced by voluntary running in vivo.

  7. Ebp1 (show NFKB1 Antibodies) p42 (show EPB42 Antibodies) isoform regulates the proteasomal degradation of the p85 (show ECM1 Antibodies) regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70 (show HSP70 Antibodies)/CHIP.

  8. CHIP as a novel causative gene for autosomal recessive cerebellar ataxia (show USP14 Antibodies)

  9. CHIP inhibits NF-kappaB (show NFKB1 Antibodies) signaling by promoting TRAF6 (show TRAF6 Antibodies) degradation and plays an important role in osteoclastogenesis and bone remodeling.

  10. regulation of IL-4 (show IL4 Antibodies) receptor signaling in lung inflammation

Human STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. Cdk5 (show CDK5 Antibodies)-mediated phosphorylation of CHIP negatively regulates its neuroprotective function, thereby contributing to neuronal cell death progression following neurotoxic stimuli.

  2. CHIP is a bona fide negative regulator of the RIPK1 (show RIPK1 Antibodies)-RIPK3 (show RIPK3 Antibodies) necrosome formation leading to desensitization of TNF (show TNF Antibodies)-mediated necroptosis

  3. Protein-protein interactions modulate the docking-dependent E3-ubiquitin ligase (show MUL1 Antibodies) activity of CHIP.

  4. Data show that the E3 ubiquitin ligase (show MUL1 Antibodies) CHIP interacts with protein arginine methyltransferase-5 (PRMT5 (show PRMT5 Antibodies)) both in vivo and in vitro.

  5. These results indicate that CHIP decreases the Kv1.5 (show KCNA5 Antibodies) protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 (show HSPA8 Antibodies)

  6. detailed and systematic investigation to characterize if there are significant differences in the CHIP in vitro ubiquitination of human Hsp70 (show HSP70 Antibodies) and Hsc70 (show HSPA8 Antibodies).

  7. CHIP stabilizes amyloid precursor protein (show APP Antibodies) via proteasomal degradation and p53 (show TP53 Antibodies)-mediated trans-repression of BACE1 (show BACE Antibodies).

  8. Our findings demonstrate for the first time that CHIP may be involved in RCC (show XRCC1 Antibodies) angiogenesis through regulating VEGF (show VEGFA Antibodies) secretion and expression of VEGFR2 (show KDR Antibodies).

  9. results indicate that the post-endocytic ubiquitination of CFTR (show CFTR Antibodies) by CHIP is a critical step in the peripheral quality control of cell surface DeltaF508 CFTR (show CFTR Antibodies)

  10. CHIP docks onto Hsp70/Hsc70 and defines a bipartite mode of interaction between TPR domains and their binding partners.

STIP1 Homology and U-Box Containing Protein 1 (STUB1) Antigen Profile

Protein Summary

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008

Gene names and symbols associated with STUB1

  • STIP1 homology and U-box containing protein 1 (STUB1) antibody
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (stub1) antibody
  • STIP1 homology and U box-containing protein 1 (LOC100282870) antibody
  • E3 ubiquitin-protein ligase CHIP (CHIP) antibody
  • SET domain containing 1B (SETD1B) antibody
  • STIP1 homology and U-Box containing protein 1 (Stub1) antibody
  • STIP1 homology and U-Box containing protein 1 (stub1) antibody
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (STUB1) antibody
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (Stub1) antibody
  • 0610033N24Rik antibody
  • 2210017D18Rik antibody
  • 2310040B03Rik antibody
  • ATCHIP antibody
  • AW046544 antibody
  • carboxyl terminus of HSC70-interacting protein antibody
  • CHIP antibody
  • HSPABP2 antibody
  • NY-CO-7 antibody
  • SDCCAG7 antibody
  • STUB1 antibody
  • UBOX1 antibody
  • wu:fc22f04 antibody
  • zgc:56076 antibody

Protein level used designations for STUB1

STIP1 homology and U-box containing protein 1 , STIP1 homology and U box-containing protein 1 , E3 ubiquitin-protein ligase CHIP , carboxy terminus of Hsp70-interacting protein , CHIP , CLL-associated antigen KW-8 , antigen NY-CO-7 , heat shock protein A binding protein 2 (c-terminal) , serologically defined colon cancer antigen 7 , STIP1 homology and U-Box containing protein 1

GENE ID SPECIES
453803 Pan troglodytes
479892 Canis lupus familiaris
697105 Macaca mulatta
779800 Xenopus (Silurana) tropicalis
100282870 Zea mays
819925 Arabidopsis thaliana
514102 Bos taurus
56424 Mus musculus
324243 Danio rerio
10273 Homo sapiens
287155 Rattus norvegicus
733415 Xenopus laevis
426918 Gallus gallus
504565 Bos taurus
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