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STIP1 Homology and U-Box Containing Protein 1 Proteins (STUB1)

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009].. Additionally we are shipping STIP1 Homology and U-Box Containing Protein 1 Antibodies (103) and STIP1 Homology and U-Box Containing Protein 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STUB1 56424 Q9WUD1
STUB1 10273 Q9UNE7
Rat STUB1 STUB1 287155  
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Top STIP1 Homology and U-Box Containing Protein 1 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$273.57
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,728.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 2 to 3 Days
$315.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$190.93
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 10 to 12 Days
$237.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 3 to 4 Days
$486.07
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

STUB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for STIP1 Homology and U-Box Containing Protein 1 (STUB1) Interaction Partners

Arabidopsis thaliana STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. Through selective degradation of Clp subunits, AtCHIP could positively regulate homeostasis of Clp proteolytic subunits and maximize the production of functional chloroplasts. Similar results were obtained from transgenic tobacco plants.

  2. we propose that CHIP and NBR1 (show NBR1 Proteins) mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation

  3. Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (show Psmd4 Proteins) system.

  4. AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]

  5. The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.

Mouse (Murine) STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. PABPN1 (show PABPN1 Proteins) interacts with and is stabilized by heat shock protein 90 (show HSP90 Proteins).

  2. CHIP targets Osx (show SP7 Proteins) for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (show TNF Proteins).

  3. CHIP/TRAF3 (show TRAF3 Proteins)/NIK (show MAP4K4 Proteins) interactions recruit NIK (show MAP4K4 Proteins) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 Proteins) at low levels

  4. Cbl-b, together with Stub1, ubiquitinate Foxp3 (show FOXP3 Proteins), and regulate tTreg development.

  5. CHIP regulates the levels of FMR1 (show FMR1 Proteins) as an E3 ubiquitin ligase (show MUL1 Proteins) in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1 (show FMR1 Proteins)-mediated translational repression by regulating the levels of FMR1 (show FMR1 Proteins).

  6. The cardiac CHIP appears to play a role in regulating autophagy during the development of cardiac hypertrophy, possibly by its role in supporting Akt (show AKT1 Proteins) signalling, induced by voluntary running in vivo.

  7. Ebp1 (show NFKB1 Proteins) p42 (show EPB42 Proteins) isoform regulates the proteasomal degradation of the p85 (show ECM1 Proteins) regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70 (show HSP70 Proteins)/CHIP.

  8. CHIP as a novel causative gene for autosomal recessive cerebellar ataxia (show USP14 Proteins)

  9. CHIP inhibits NF-kappaB (show NFKB1 Proteins) signaling by promoting TRAF6 (show TRAF6 Proteins) degradation and plays an important role in osteoclastogenesis and bone remodeling.

  10. regulation of IL-4 (show IL4 Proteins) receptor signaling in lung inflammation

Human STIP1 Homology and U-Box Containing Protein 1 (STUB1) interaction partners

  1. Cdk5 (show CDK5 Proteins)-mediated phosphorylation of CHIP negatively regulates its neuroprotective function, thereby contributing to neuronal cell death progression following neurotoxic stimuli.

  2. CHIP is a bona fide negative regulator of the RIPK1 (show RIPK1 Proteins)-RIPK3 (show RIPK3 Proteins) necrosome formation leading to desensitization of TNF (show TNF Proteins)-mediated necroptosis

  3. Protein-protein interactions modulate the docking-dependent E3-ubiquitin ligase (show MUL1 Proteins) activity of CHIP.

  4. Data show that the E3 ubiquitin ligase (show MUL1 Proteins) CHIP interacts with protein arginine methyltransferase-5 (PRMT5 (show PRMT5 Proteins)) both in vivo and in vitro.

  5. These results indicate that CHIP decreases the Kv1.5 (show KCNA5 Proteins) protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 (show HSPA8 Proteins)

  6. detailed and systematic investigation to characterize if there are significant differences in the CHIP in vitro ubiquitination of human Hsp70 (show HSP70 Proteins) and Hsc70 (show HSPA8 Proteins).

  7. CHIP stabilizes amyloid precursor protein (show APP Proteins) via proteasomal degradation and p53 (show TP53 Proteins)-mediated trans-repression of BACE1 (show BACE Proteins).

  8. Our findings demonstrate for the first time that CHIP may be involved in RCC (show XRCC1 Proteins) angiogenesis through regulating VEGF (show VEGFA Proteins) secretion and expression of VEGFR2 (show KDR Proteins).

  9. results indicate that the post-endocytic ubiquitination of CFTR (show CFTR Proteins) by CHIP is a critical step in the peripheral quality control of cell surface DeltaF508 CFTR (show CFTR Proteins)

  10. CHIP docks onto Hsp70/Hsc70 and defines a bipartite mode of interaction between TPR domains and their binding partners.

STIP1 Homology and U-Box Containing Protein 1 (STUB1) Protein Profile

Protein Summary

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008

Gene names and symbols associated with STUB1

  • STIP1 homology and U-box containing protein 1 (STUB1)
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (stub1)
  • STIP1 homology and U box-containing protein 1 (LOC100282870)
  • E3 ubiquitin-protein ligase CHIP (CHIP)
  • SET domain containing 1B (SETD1B)
  • STIP1 homology and U-Box containing protein 1 (Stub1)
  • STIP1 homology and U-Box containing protein 1 (stub1)
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (STUB1)
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (Stub1)
  • 0610033N24Rik protein
  • 2210017D18Rik protein
  • 2310040B03Rik protein
  • ATCHIP protein
  • AW046544 protein
  • carboxyl terminus of HSC70-interacting protein protein
  • CHIP protein
  • HSPABP2 protein
  • NY-CO-7 protein
  • SDCCAG7 protein
  • STUB1 protein
  • UBOX1 protein
  • wu:fc22f04 protein
  • zgc:56076 protein

Protein level used designations for STUB1

STIP1 homology and U-box containing protein 1 , STIP1 homology and U box-containing protein 1 , E3 ubiquitin-protein ligase CHIP , carboxy terminus of Hsp70-interacting protein , CHIP , CLL-associated antigen KW-8 , antigen NY-CO-7 , heat shock protein A binding protein 2 (c-terminal) , serologically defined colon cancer antigen 7 , STIP1 homology and U-Box containing protein 1

GENE ID SPECIES
453803 Pan troglodytes
479892 Canis lupus familiaris
697105 Macaca mulatta
779800 Xenopus (Silurana) tropicalis
100282870 Zea mays
819925 Arabidopsis thaliana
514102 Bos taurus
56424 Mus musculus
324243 Danio rerio
10273 Homo sapiens
287155 Rattus norvegicus
733415 Xenopus laevis
426918 Gallus gallus
504565 Bos taurus
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