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The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Additionally we are shipping STT3B Antibodies (8) and many more products for this protein.
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STT3B was significantly upregulated in hip osteoarthritis with affected versus intact cartilage, particularly in the analysis of hypertrophic and normotrophic compared with atrophic bone remodelling pattern.
Post-translational modification of cotranslationally skipped sites by STT3B is hindered by the middle X residue, resulting in hypoglycosylation of consensus sites containing large hydrophobic and negatively charged side chains.
Results show homozygous mutation in STT3A (show STT3A Proteins) and in STT3B causes congenital disorders of glycosylation.
Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST (show DDOST Proteins).
Data show that prolonged transthyretin (TTR (show TTR Proteins)) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation.
The STT3B isoform is required for efficient cotranslational glycosylation of an acceptor site adjacent to the N-terminal signal sequence of a secreted protein.
STT3 proteins are the catalytic subunits of the oligosaccharyltransferase. Vertebrate, plant and insect genomes have an STT3A (show STT3A Proteins) gene and a STT3B gene. SIMP is a member of the STT3B subfamily of STT3 proteins.
The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation (McBride et al., 2002
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
, source of immunodominant MHC-associated peptides
, B6dom1 antigen
, oligosaccharyl transferase subunit STT3B
, STT3, subunit of the oligosaccharyltransferase complex, homolog B
, dolichyl-diphosphooligosaccharide protein glycotransferase
, homolog of yeast STT3
, source of immunodominant MHC associated peptides
, source of immunodominant MHC-associated peptides homolog