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SUMO1 Activating Enzyme Subunit 1 Proteins (SAE1)

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Additionally we are shipping SAE1 Antibodies (126) and SAE1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SAE1 57514 Q2M1Z3
SAE1 56459 Q9R1T2
Rat SAE1 SAE1 308384 Q6AXQ0
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Top SAE1 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,933.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,938.83
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,938.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,942.50
Details
HOST_Escherichia coli (E. coli) Human T7 tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details

SAE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Top referenced SAE1 Proteins

  1. Human SAE1 Protein expressed in Escherichia coli (E. coli) - ABIN667139 : Boggio, Passafaro, Chiocca: Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN667139

  2. Human SAE1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005993 : Tatham, Jaffray, Vaughan, Desterro, Botting, Naismith, Hay: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. in The Journal of biological chemistry 2001 (PubMed)

More Proteins for SUMO1 Activating Enzyme Subunit 1 (SAE1) Interaction Partners

Human SUMO1 Activating Enzyme Subunit 1 (SAE1) interaction partners

  1. the expression of SENP8 (show SENP8 Proteins), SAE1, PIAS1 (show PIAS1 Proteins), PIAS2 (show PIAS2 Proteins) and ZMIZ1 is deregulated in the majority of PTC (show F9 Proteins) tissues, likely contributing to the PTC (show F9 Proteins) phenotype.

  2. as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells.

  3. a four-generation pedigree with isolated terminal limb defects and a truncating mutation in ARHGAP31 underscores the relevance of sequencing ARHGAP31 in cases of isolated limb defects, irrespective of presence of a complete Adams-Oliver syndrome phenotype

  4. The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.

  5. Data demonstrate that cdGAP negatively regulates directed and random migration by controlling adhesion maturation and dynamics through the regulation of both adhesion assembly and disassembly.

  6. Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 (show RBBP8 Proteins) antibody as marker of dermatomyositis.

  7. specific interaction between negatively charged phospholipid PI(3,4,5)P3 and the stretch of polybasic residues preceding the RhoGAP domain regulates CdGAP activity in vivo and is required for its cellular functions.

  8. Data show that the SAE2 (show RBBP8 Proteins) subunit of the small ubiquitin-like modifier (SUMO (show SUMO1 Proteins)) E1 is autoSUMOylated at residue Lys (show LYZ Proteins)-236, and SUMOylation was catalyzed by Ubc9 (show UBE2I Proteins) at several additional Lys (show LYZ Proteins) residues surrounding the catalytic Cys (show DNAJC5 Proteins)-173 of SAE2 (show RBBP8 Proteins).

  9. loss of SAE1/2 activity drives synthetic lethality with Myc (show MYC Proteins); inactivation of SAE2 (show RBBP8 Proteins) leads to mitotic catastrophe and cell death upon Myc (show MYC Proteins) hyperactivation; findings in Myc (show MYC Proteins)-high breast cancers suggest low tumor SAE1 and SAE2 (show RBBP8 Proteins) correlates metastasis-free survival

  10. Rho GTPase activating protein 31

SAE1 Protein Profile

Protein Summary

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999

Gene names and symbols associated with SAE1

  • Rho GTPase activating protein 31 (ARHGAP31)
  • SUMO1 activating enzyme subunit 1 (SAE1)
  • SUMO1 activating enzyme subunit 1 (Sae1)
  • SUMO1 activating enzyme subunit 1 (sae1)
  • 2400010M20Rik protein
  • 2610044L12Rik protein
  • AL033372 protein
  • aos protein
  • AOS1 protein
  • Aos1p protein
  • AW743391 protein
  • CDGAP protein
  • D7Ertd177e protein
  • HSPC140 protein
  • Sua1 protein
  • Sua1p protein
  • Uble1a protein

Protein level used designations for SAE1

Cdc42 GTPase-activating protein , rho GTPase-activating protein 31 , SUMO-1 activating enzyme E1 N subunit , SUMO-1 activating enzyme subunit 1 , SUMO-activating enzyme subunit 1 , activator of SUMO1 , sentrin/SUMO-activating protein AOS1 , ubiquitin-like 1-activating enzyme E1A , ubiquitin-like protein SUMO-1 activating enzyme , ubiquitin-like (sentrin) activating enzyme E1A , ubiquitin-like 1 (sentrin) activating enzyme E1A , ubiquitin-like 1 (sentrin) activating enzyme subunit 1 , SUMO-activating enzyme E1 N subunit

GENE ID SPECIES
57514 Homo sapiens
10055 Homo sapiens
56459 Mus musculus
308384 Rattus norvegicus
505512 Bos taurus
476425 Canis lupus familiaris
100173973 Pongo abelii
443558 Xenopus laevis
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