SUMO1 Activating Enzyme Subunit 1 Proteins (SAE1)

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Additionally we are shipping SAE1 Antibodies (131) and SAE1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SAE1 10055 Q9UBE0
SAE1 56459 Q9R1T2
Rat SAE1 SAE1 308384 Q6AXQ0
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Top SAE1 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$319.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,933.33
Details
Yeast Pongo abelii His tag   1 mg Log in to see 60 to 71 Days
$2,938.83
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,938.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,942.50
Details

SAE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

More Proteins for SUMO1 Activating Enzyme Subunit 1 (SAE1) Interaction Partners

Human SUMO1 Activating Enzyme Subunit 1 (SAE1) interaction partners

  1. the expression of SENP8 (show SENP8 Proteins), SAE1, PIAS1 (show PIAS1 Proteins), PIAS2 (show PIAS2 Proteins) and ZMIZ1 is deregulated in the majority of PTC (show F9 Proteins) tissues, likely contributing to the PTC (show F9 Proteins) phenotype.

  2. as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells.

  3. Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 (show RBBP8 Proteins) antibody as marker of dermatomyositis.

  4. Data show that the SAE2 (show RBBP8 Proteins) subunit of the small ubiquitin-like modifier (SUMO (show SUMO1 Proteins)) E1 is autoSUMOylated at residue Lys (show LYZ Proteins)-236, and SUMOylation was catalyzed by Ubc9 (show UBE2I Proteins) at several additional Lys (show LYZ Proteins) residues surrounding the catalytic Cys (show DNAJC5 Proteins)-173 of SAE2 (show RBBP8 Proteins).

  5. loss of SAE1/2 activity drives synthetic lethality with Myc (show MYC Proteins); inactivation of SAE2 (show RBBP8 Proteins) leads to mitotic catastrophe and cell death upon Myc (show MYC Proteins) hyperactivation; findings in Myc (show MYC Proteins)-high breast cancers suggest low tumor SAE1 and SAE2 (show RBBP8 Proteins) correlates metastasis-free survival

  6. The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.

  7. structures of heterodimeric Sae1/Sae2 (show RBBP8 Proteins)-Mg.ATP and Sae1/Sae2 (show RBBP8 Proteins)-SUMO-1 (show SUMO1 Proteins)-Mg.ATP complexes

  8. SUMO-1 (show SUMO1 Proteins) controls the protein stability and the biological function of phosducin (show PDC Proteins).

Zebrafish SUMO1 Activating Enzyme Subunit 1 (SAE1) interaction partners

  1. sae1 is essential for the maintenance of hematopoietic stem/progenitor cells during fetal hematopoiesis in zebrafish.

SAE1 Protein Profile

Protein Summary

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999

Gene names and symbols associated with SAE1

  • SUMO1 activating enzyme subunit 1 (SAE1)
  • SUMO1 activating enzyme subunit 1 (Sae1)
  • SUMO1 activating enzyme subunit 1 L homeolog (sae1.L)
  • SUMO1 activating enzyme subunit 1 (sae1)
  • 2400010M20Rik protein
  • 2610044L12Rik protein
  • AL033372 protein
  • aos protein
  • AOS1 protein
  • Aos1p protein
  • AW743391 protein
  • D7Ertd177e protein
  • HSPC140 protein
  • sae2a protein
  • Sua1 protein
  • Sua1p protein
  • uble1a protein
  • wu:fa28b04 protein
  • zgc:86633 protein

Protein level used designations for SAE1

SUMO-1 activating enzyme E1 N subunit , SUMO-1 activating enzyme subunit 1 , SUMO-activating enzyme subunit 1 , activator of SUMO1 , sentrin/SUMO-activating protein AOS1 , ubiquitin-like 1-activating enzyme E1A , ubiquitin-like protein SUMO-1 activating enzyme , ubiquitin-like (sentrin) activating enzyme E1A , ubiquitin-like 1 (sentrin) activating enzyme E1A , ubiquitin-like 1 (sentrin) activating enzyme subunit 1 , SUMO-activating enzyme E1 N subunit , SUMO1 activating enzyme subunit 2a , Ubiquitin-like 1-activating enzyme E1A , fa28b04

GENE ID SPECIES
10055 Homo sapiens
56459 Mus musculus
308384 Rattus norvegicus
476425 Canis lupus familiaris
505512 Bos taurus
100173973 Pongo abelii
443558 Xenopus laevis
100718649 Cavia porcellus
415148 Danio rerio
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