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Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Additionally we are shipping SAE1 Antibodies (131) and SAE1 Kits (11) and many more products for this protein.
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Study demonstrate that CdGAP acts as a novel co-transcriptional repressor with Zeb2 to suppress E-cadherin (show CDH1 Proteins) expression in breast cancer cells.
the expression of SENP8 (show SENP8 Proteins), SAE1, PIAS1 (show PIAS1 Proteins), PIAS2 (show PIAS2 Proteins) and ZMIZ1 is deregulated in the majority of PTC (show F9 Proteins) tissues, likely contributing to the PTC (show F9 Proteins) phenotype.
as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells.
a four-generation pedigree with isolated terminal limb defects and a truncating mutation in ARHGAP31 underscores the relevance of sequencing ARHGAP31 in cases of isolated limb defects, irrespective of presence of a complete Adams-Oliver syndrome phenotype
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.
Data demonstrate that cdGAP negatively regulates directed and random migration by controlling adhesion maturation and dynamics through the regulation of both adhesion assembly and disassembly.
Data indicate the role of anti-SUMO activating enzyme SAE1 and SAE2 (show RBBP8 Proteins) antibody as marker of dermatomyositis.
specific interaction between negatively charged phospholipid PI(3,4,5)P3 and the stretch of polybasic residues preceding the RhoGAP domain regulates CdGAP activity in vivo and is required for its cellular functions.
Data show that the SAE2 (show RBBP8 Proteins) subunit of the small ubiquitin-like modifier (SUMO (show SUMO1 Proteins)) E1 is autoSUMOylated at residue Lys (show LYZ Proteins)-236, and SUMOylation was catalyzed by Ubc9 (show UBE2I Proteins) at several additional Lys (show LYZ Proteins) residues surrounding the catalytic Cys (show DNAJC5 Proteins)-173 of SAE2 (show RBBP8 Proteins).
loss of SAE1/2 activity drives synthetic lethality with Myc (show MYC Proteins); inactivation of SAE2 (show RBBP8 Proteins) leads to mitotic catastrophe and cell death upon Myc (show MYC Proteins) hyperactivation; findings in Myc (show MYC Proteins)-high breast cancers suggest low tumor SAE1 and SAE2 (show RBBP8 Proteins) correlates metastasis-free survival
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
Cdc42 GTPase-activating protein
, rho GTPase-activating protein 31
, SUMO-1 activating enzyme E1 N subunit
, SUMO-1 activating enzyme subunit 1
, SUMO-activating enzyme subunit 1
, activator of SUMO1
, sentrin/SUMO-activating protein AOS1
, ubiquitin-like 1-activating enzyme E1A
, ubiquitin-like protein SUMO-1 activating enzyme
, ubiquitin-like (sentrin) activating enzyme E1A
, ubiquitin-like 1 (sentrin) activating enzyme E1A
, ubiquitin-like 1 (sentrin) activating enzyme subunit 1
, SUMO-activating enzyme E1 N subunit