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SUMO1 Activating Enzyme Subunit 2 Proteins (UBA2)

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Additionally we are shipping SUMO1 Activating Enzyme Subunit 2 Antibodies (71) and SUMO1 Activating Enzyme Subunit 2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBA2 10054 Q9UBT2
UBA2 50995 Q9Z1F9
Rat UBA2 UBA2 308508  
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Top SUMO1 Activating Enzyme Subunit 2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UBA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for SUMO1 Activating Enzyme Subunit 2 (UBA2) Interaction Partners

Human SUMO1 Activating Enzyme Subunit 2 (UBA2) interaction partners

  1. Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus.

  2. Data indicate the role of anti-SUMO activating enzyme SAE1 (show SAE1 Proteins) and SAE2 (show RBBP8 Proteins) antibody as marker of dermatomyositis.

  3. Data show that the SAE2 (show RBBP8 Proteins) subunit of the small ubiquitin-like modifier (SUMO (show SUMO1 Proteins)) E1 is autoSUMOylated at residue Lys (show LYZ Proteins)-236, and SUMOylation was catalyzed by Ubc9 (show UBE2I Proteins) at several additional Lys (show LYZ Proteins) residues surrounding the catalytic Cys (show DNAJC5 Proteins)-173 of SAE2 (show RBBP8 Proteins).

  4. loss of SAE1 (show SAE1 Proteins)/2 activity drives synthetic lethality with Myc (show MYC Proteins); inactivation of SAE2 (show RBBP8 Proteins) leads to mitotic catastrophe and cell death upon Myc (show MYC Proteins) hyperactivation; findings in Myc (show MYC Proteins)-high breast cancers suggest low tumor SAE1 (show SAE1 Proteins) and SAE2 (show RBBP8 Proteins) correlates metastasis-free survival

  5. The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 (show SAE1 Proteins) and in Uba2, and demonstrate that their import is mediated by importin alpha (show KPNA4 Proteins)/beta in vitro and in intact cells.

  6. structures of heterodimeric Sae1 (show SAE1 Proteins)/Sae2 (show RBBP8 Proteins)-Mg.ATP and Sae1 (show SAE1 Proteins)/Sae2 (show RBBP8 Proteins)-SUMO-1 (show SUMO1 Proteins)-Mg.ATP complexes

  7. UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis.

SUMO1 Activating Enzyme Subunit 2 (UBA2) Protein Profile

Protein Summary

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999

Gene names and symbols associated with UBA2

  • SUMO1 activating enzyme subunit 2 (MICPUN_63834)
  • SUMO1 activating enzyme subunit 2 (MICPUCDRAFT_36729)
  • SUMO-activating enzyme subunit 2 (SAE2)
  • ubiquitin-like modifier activating enzyme 2 (UBA2)
  • ubiquitin-like modifier activating enzyme 2 (Uba2)
  • ubiquitin-like modifier activating enzyme 2 (uba2)
  • AA986091 protein
  • Arx protein
  • ATSAE2 protein
  • EMB2764 protein
  • EMBRYO DEFECTIVE 2764 protein
  • F3K23.23 protein
  • F3K23_23 protein
  • sae2 protein
  • sae2-B protein
  • sae2b protein
  • SUMO-activating enzyme 2 protein
  • UBA1 protein
  • uba2-a protein
  • uba2-b protein
  • Ubl1a2 protein
  • uble1b protein
  • uble1b-B protein
  • wu:fi17g06 protein
  • zgc:66354 protein

Protein level used designations for UBA2

SUMO1 activating enzyme subunit 2 , SUMO-1 activating enzyme subunit 2 , SUMO-activating enzyme subunit 2 , UBA2, ubiquitin-activating enzyme E1 homolog , anthracycline-associated resistance ARX , ubiquitin-like 1-activating enzyme E1B , Sumo-1 activating enzyme subunit 2 , ubiquitin-like 1 (sentrin) activating enzyme E1B , ubiquitin-like 1 (sentrin) activating enzyme subunit 2 , SUMO-activating enzyme subunit 2-A , SUMO-activating enzyme subunit 2-B , ubiquitin-like 1-activating enzyme E1B-A , ubiquitin-like 1-activating enzyme E1B-B , SUMO1 activating enzyme subunit 2b

GENE ID SPECIES
8248549 Micromonas sp. RCC299
9689179 Micromonas pusilla CCMP1545
816686 Arabidopsis thaliana
10054 Homo sapiens
50995 Mus musculus
308508 Rattus norvegicus
476490 Canis lupus familiaris
399235 Xenopus laevis
406672 Danio rerio
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