You are viewing an incomplete version of our website. Please click to reload the website as full version.

SUMO1/sentrin Specific Peptidase 1 Proteins (SENP1)

SENP1 encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. Additionally we are shipping SENP1 Antibodies (105) and SENP1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SENP1 29843 Q9P0U3
SENP1 223870 P59110
Rat SENP1 SENP1 300193  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SENP1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
$250.95
Details

SENP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SUMO1/sentrin Specific Peptidase 1 (SENP1) Interaction Partners

Xenopus laevis SUMO1/sentrin Specific Peptidase 1 (SENP1) interaction partners

  1. XSENP1a and XSENP1b are sumo-specific proteases that inhibit normal head formation by inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

Human SUMO1/sentrin Specific Peptidase 1 (SENP1) interaction partners

  1. Genetic interactions of SNPs in CARD14 (show CARD14 Proteins), SENP1 and VEGFA (show VEGFA Proteins) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.

  2. SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1alpha (show HIF1A Proteins)

  3. SENP1 expression has strong prognostic impact in a molecularly defined subset of cancers. This is per se not surprising as the biologic impact of each individual molecular event is likely to be dependent on its cellular environment.

  4. SENP1 was expressed in human islets, and its mRNA level was unchanged in islets from donors with T2D. In cultured islets, overexpressed SENP1-GFP colocalized with secretory granules at the plasma membrane

  5. SENP1 uses remote substrate binding for conformational flexibility and activation

  6. SENP1 up-regulation in diseased heart is mediated via calcineurin-NFAT/MEF2C-PGC-1alpha pathway.

  7. results provide independent evidence in support of a role for SENP1 in chronic mountain sickness in individuals of Quechua ancestry and suggest the SENP1 and ANP32D signatures of selection are in tight linkage disequilibrium (LD).

  8. Over-expression of small ubiquitin-like modifier (show SUMO1 Proteins) proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer.(

  9. low expression of miR (show MLXIP Proteins)-145 was correlated with high expression of SENP1 in Prostate cancer cell line and the SENP1 3'-untranslated region was a regulative target of miR (show MLXIP Proteins)-145 in vitro.

  10. results delineate a key role for Senp1in IL-6 (show IL6 Proteins) induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM

Mouse (Murine) SUMO1/sentrin Specific Peptidase 1 (SENP1) interaction partners

  1. SENP1 deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO (show IKBKG Proteins), leading to increased NF-kappaB (show NFKB1 Proteins) activity, cytokine production and pancreatic inflammation.

  2. results of the present study are of both theoretical and therapeutic significance to explore the potential roles of SENP1 under IH condition and elucidated the mechanisms underlying microglial survival and activation

  3. A role for islet SENP1 as a regulator of in vivo glucose homeostasis was demonstrated by the tissue-selective and inducible knockout of this enzyme.

  4. SENP1 up-regulation in diseased heart is mediated via calcineurin-NFAT/MEF2C-PGC-1alpha pathway.

  5. SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha (show HIF1A Proteins)-dependent pathway.

  6. SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1 (show BHLHE41 Proteins), which then releases Sharp-1 (show BHLHE41 Proteins) repression of PPARgamma (show PPARG Proteins) expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis.

  7. Senp1 Is the Primary Activity for Desumoylation of Sumo1 (show SUMO1 Proteins)-Modified Proteins.

  8. SENP1 is a specific SUMO protease to regulate SUMOylation status of PGC-1alpha.

  9. SENP1 is essential for cell survival during endoplasmic reticulum stress.

  10. SENP1 is essential for the development of early T and B cells.

SENP1 Protein Profile

Protein Summary

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with SENP1

  • SUMO1/sentrin specific peptidase 1 (SENP1)
  • sentrin/SUMO-specific protease 1 (Senp1)
  • similar to Sentrin-specific protease 1 (Sentrin/SUMO-specific protease SENP1) (SENP1)
  • SUMO1/sentrin specific peptidase 1 (senp1-b)
  • SUMO1/sentrin specific peptidase 1 (senp1)
  • SUMO1/sentrin specific peptidase 1 (Senp1)
  • SUMO1/sentrin specific peptidase 1 (senp1-a)
  • 2310046A20Rik protein
  • D15Ertd528e protein
  • E330036L07Rik protein
  • senp1 protein
  • senp1a protein
  • senp1b protein
  • suPr-2 protein
  • xsenp1 protein

Protein level used designations for SENP1

sentrin-specific protease 1 , SUMO1/sentrin specific peptidase 1 , sentrin/SUMO-specific protease 1 , similar to Sentrin-specific protease 1 (Sentrin/SUMO-specific protease SENP1) , sentrin/SUMO-specific protease SENP1 , sentrin specific protease 1b , SUMO1/sentrin specific protease 1 , SUMO-1 protease 2 , SUMO-specific protease U1p1 , sentrin specific protease 1a , Sumo1/sentrin/SMT3 specific peptidase 1

GENE ID SPECIES
477629 Canis lupus familiaris
538091 Bos taurus
100157986 Sus scrofa
426185 Gallus gallus
451862 Pan troglodytes
548976 Xenopus (Silurana) tropicalis
707603 Macaca mulatta
714066 Macaca mulatta
100056855 Equus caballus
100190851 Pongo abelii
100329216 Xenopus laevis
100547302 Meleagris gallopavo
100553998 Anolis carolinensis
29843 Homo sapiens
223870 Mus musculus
398517 Xenopus laevis
300193 Rattus norvegicus
Selected quality suppliers for SENP1 Proteins (SENP1)
Did you look for something else?