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The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for numerous biologic processes. Additionally we are shipping SENP5 Antibodies (95) and SENP5 Proteins (4) and many more products for this protein.
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Mild oxidative stress stabilized the SENP5 protein in the oral squamous cell carcinoma cells, and only the combination of SENP5 silencing and H2O2 application led to mitochondria fragmentation and a significant increase in cell apoptosis.
Low expression of SENP5 is associated with good prognosis among breast cancer patients.
Knockdown of SENP5 resulted in increased levels of SUMO-1 (show SUMO1 ELISA Kits) and SUMO-2 (show SUMO2 ELISA Kits)/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis.
altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC.
Nucleolar protein (show MCRS1 ELISA Kits) B23/nucleophosmin (show NPM1 ELISA Kits) regulates the vertebrate SUMO pathway through SENP3 (show ULP1 ELISA Kits) and SENP5 proteases.
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006
SUMO/Smt3-specific isopeptidase 3
, SUMO/sentrin specific protease 5
, sentrin-specific protease 5
, sentrin/SUMO-specific protease SENP5
, SUMO1/sentrin specific protease 5
, Sumo1/sentrin/SMT3 specific peptidase 5