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SUMO1/sentrin Specific Protease 6 Proteins (SENP6)

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1\; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. Additionally we are shipping SENP6 Antibodies (121) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SENP6 215351 Q6P7W0
SENP6 26054 Q9GZR1
Rat SENP6 SENP6 300860  
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Top SENP6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

SENP6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for SUMO1/sentrin Specific Protease 6 (SENP6) Interaction Partners

Mouse (Murine) SUMO1/sentrin Specific Protease 6 (SENP6) interaction partners

  1. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.

Human SUMO1/sentrin Specific Protease 6 (SENP6) interaction partners

  1. our data suggest that SENP6, which is highly expressed in gastric cancer cells, regulates the transcriptional activity and stability of FoxM1 (show FOXM1 Proteins) through deSUMOylation.

  2. the structure of SENP2 (show SUMO1 Proteins)-Loop1 in complex with SUMO2 (show SUMO2 Proteins) was solved at 2.15 A resolution, and reveals the details of an interface exclusive to SENP6/7 and the formation of unique contacts between both proteins

  3. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.

  4. study of substrate specificity of SENP6; it is also capable of cleaving mixed chains of SUMO-1 (show SUMO1 Proteins) and SUMO-2 (show SUMO2 Proteins)/3; mutation of catalytic cysteine of results in its accumulation in PML (show PML Proteins) NBs (show NBN Proteins); findings indicate SUMO-modified PML (show PML Proteins) is a substrate of SENP6

  5. Results reveal a novel mechanism whereby the finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components.

  6. SENP1 (show SENP1 Proteins) localization is influenced by expression and localization of SUMO-1 (show SUMO1 Proteins)-conjugated target proteins within the cell.

  7. SUSP1 plays an important role in the control of the transcriptional activity of RXRalpha (show RXRA Proteins) and thus in the RXRalpha (show RXRA Proteins)-mediated cellular processes

  8. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. SUSP1 has a strong paralogue bias toward SUMO2 (show SUMO2 Proteins)/3 and acts preferentially on substrates containing three or more SUMO2 (show SUMO2 Proteins)/3 moieties

  9. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2

SENP6 Protein Profile

Protein Summary

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1\; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA\; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000

Gene names and symbols associated with SENP6

  • SUMO1/sentrin specific peptidase 6 (SENP6)
  • SUMO/sentrin specific peptidase 6 (Senp6)
  • SUMO1/sentrin specific peptidase 6 (Senp6)
  • 2810017C20Rik protein
  • E130319N12Rik protein
  • mKIAA0797 protein
  • SSP1 protein
  • SUSP1 protein

Protein level used designations for SENP6

SUMO1/sentrin specific peptidase 6 , SUMO1/sentrin specific protease 6 , SUMO-1-specific protease 1 , SUMO/sentrin specific protease 6 , sentrin-specific protease 6 , sentrin/SUMO-specific protease SENP6 , 2810017C20Rik , SUMO/sentrin specific peptidase 6 , Sumo1/sentrin/SMT3 specific peptidase 6

GENE ID SPECIES
462829 Pan troglodytes
215351 Mus musculus
481883 Canis lupus familiaris
26054 Homo sapiens
300860 Rattus norvegicus
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